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Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line
16 May 2012
K. Pěnčíková, P. Kollár, V. Müller Závalová, E. Táborská, J. Urbanová, J. Hošek
Graphical abstract: Abstract: Quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine have been used in folk medicine for their wide range of useful properties. One of their major e...
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Borapetoside C from Tinospora crispa improves insulin sensitivity in diabetic mice
11 May 2012
Chi-Tun Ruan, Sio-Hong Lam, Tzong-Cherng Chi, Shoei-Sheng Lee, Ming-Jai Su
Graphical abstract: Abstract: Diabetes mellitus (DM) often leads to disability from vascular complications and neurological complications. Tinospora crispa has been widely used in Asia and Africa as a...
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Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures
09 May 2012
Rudolf Moldzio, Thomas Pacher, Christopher Krewenka, Barbara Kranner, Johannes Novak, Johanna Catharina Duvigneau, Wolf-Dieter Rausch
Abstract: Cannabinoids derived from Cannabis sativa demonstrate neuroprotective properties in various cellular and animal models. Mitochondrial impairment and consecutive oxidative stress appear to be...
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α-Santalol, a derivative of sandalwood oil, induces apoptosis in human prostate cancer cells by causing caspase-3 activation
09 May 2012
Ajay Bommareddy, Brittny Rule, Adam L. VanWert, Sreevidya Santha, Chandradhar Dwivedi
Graphical abstract: α-Santalol, a major component of sandalwood oil showed anti-cancer activity in prostate cancer cells by inducing apoptosis and activation of caspase-3 activity. These results provi...
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Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats
03 May 2012
Yang Cao, Weijian Bei, Yinming Hu, Le Cao, Lihua Huang, Laiyou Wang, Duosheng Luo, Yuanyuan Chen, Xi Yao, Wei He, Xiaobo Liu, Jiao Guo
Graphical abstract: Coptis alkaloids extract (CAE) showed significant hypocholesterolemic effect at least by (1) up-regulating the gene expression and activity of CYP7A1 which promotes the conversion ...
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