Phytomedicine
Volume 14, Supplement 1 , Pages 32-39, 5 March 2007

Mass spectroscopic characterisation of oligomeric proanthocyanidins derived from an extract of Pelargonium sidoides roots (EPs® 7630) and pharmacological screening in CNS models

Department of Preclinical Research, Dr. Willmar Schwabe GmbH & Co. KG, 76227 Karlsruhe, Germany

Abstract 

Chromatographic fractionation of proanthocyanidin oligomers from an aqueous ethanolic extract of Pelargonium sidoides roots (EPs® 7630) gave a diverse set of epigallo- and gallocatechin based oligomers, which are connected by A and B-type bonds. Additionally, two series of monosubstituted oligomers were detected by mass spectroscopy, sulphates and aminoconjugates. In vivo studies investigating motility, body weight gain, body temperature, motoric coordination, anticonvulsant effects and central analgesic activities, showed no or only moderate pharmacological effects, indicating, that they have no intrinsic behavioural activities.

Keywords: Pelargonium sidoides, Mass spectroscopy, Aminoconjugates, Oligomers, Proanthocyanidins, Chromatography, Behavioural Activities

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PII: S0944-7113(06)00194-2

doi:10.1016/j.phymed.2006.11.019

Phytomedicine
Volume 14, Supplement 1 , Pages 32-39, 5 March 2007

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