Phytomedicine
Volume 16, Issue 12 , Pages 1083-1088, December 2009

Inhibition of angiogenesis and inflammation by an extract of red clover (Trifolium pratense L.)

  • L. Krenn

      Affiliations

    • Department of Pharmakognosie, University Vienna, A-1090 Vienna, Austria
    • ,
  • D.H. Paper

      Affiliations

    • Anoxymer GmbH, Schelztorstraße 54-56, D-73728 Esslingen, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +0049071190121093; fax: +0049071190121099.

published online 10 August 2009.

Abstract 

Antiangiogenic compounds are gaining more and more interest as a new approach in the prevention and treatment of cancer and inflammatory diseases. The objective of this study was the evaluation of the antiangiogenic effect of a red clover extract (RCE) used in food supplements for menopausal complaints as well as of its main isoflavones in an in vivo system, the chorioallantoic membrane assay of fertilized hen's eggs. At a dosage of 250μg/pellet the red clover extract showed excellent inhibition of angiogenesis. The antiangiogenic activity of the non-methylated isoflavones daidzein and genistein was higher than that of the methylated compounds formononentin and biochanin A. The results demonstrate that RCE is not only suitable for menopausal complaints, but might also be a powerful chemopreventive agent against chronic diseases e.g. which have a high incidence especially in elderly female.

Keywords: Red clover, Trifolium pratense, CAM assay, HET-CAM assay, Antiangiogenic activity, Anti-inflammatory effect

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PII: S0944-7113(09)00158-5

doi:10.1016/j.phymed.2009.05.017

Phytomedicine
Volume 16, Issue 12 , Pages 1083-1088, December 2009

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