Phytomedicine
Volume 13, Issue 5 , Pages 352-358 , 9 May 2006

Effect of polysaccharides from Opuntia ficus-indica (L.) cladodes on the healing of dermal wounds in the rat

  • D. Trombetta

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +39906766530; fax: +39903533142.
  • ,
  • C. Puglia

      Affiliations

    • Department of Pharmaceutical Sciences, University of Catania, Italy
  • ,
  • D. Perri

      Affiliations

    • Department Farmaco-Biologico, School of Pharmacy, University of Messina, Italy
  • ,
  • A. Licata

      Affiliations

    • Department Biologia Animale & Ecologia Marina, University of Messina, Contrada Annunziata, 98168 Messina, Italy
  • ,
  • S. Pergolizzi

      Affiliations

    • Department Biologia Animale & Ecologia Marina, University of Messina, Contrada Annunziata, 98168 Messina, Italy
  • ,
  • E.R. Lauriano

      Affiliations

    • Department Biologia Animale & Ecologia Marina, University of Messina, Contrada Annunziata, 98168 Messina, Italy
  • ,
  • A. De Pasquale

      Affiliations

    • Department Farmaco-Biologico, School of Pharmacy, University of Messina, Italy
  • ,
  • A. Saija

      Affiliations

    • Department Farmaco-Biologico, School of Pharmacy, University of Messina, Italy
  • ,
  • F.P. Bonina

      Affiliations

    • Department of Pharmaceutical Sciences, University of Catania, Italy

Received 27 November 2003 ,Accepted 6 June 2005.

References 

  1. Basak PY, Eroglu E, Altuntas I, Agalar F, Basak K, Sutcu R. Comparison of the effects of tretinoin, adapalene and collagenase in an experimental model of wound healing. Eur J Dermatol. 2002;12:145–148
  2. Bedi MK, Shenefelt PD. Herbal therapy in dermatology. Arch Dermatol. 2002;138:232–242
  3. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen. 1999;7:79–89
  4. Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol Cell Biochem. 1998;181:71–76
  5. Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats. J Ethnopharmacol. 1998;59:179–186
  6. Dubois M, Gilles KA, Hamilton JK, Rebers PA, Smith F. Colorimetric method for determination of sugars and related substances. Anal Chem. 1956;28:350–356
  7. El Kossori RL, Villaume C, El Boustani E, Sauvaire Y, Mejean L. Composition of pulp, skin and seeds of prickly pears fruit (Opuntia ficus indica sp.). Plant Foods Hum Nutr. 1998;52:263–270
  8. Galati EM, Monforte MT, Tripodo MM, D’Aquino A, Mondello MR. Antiulcer activity of Opuntia ficus-indica (L.) Mill. (Cactaceae): ultrastructural study. J Ethnopharmacol. 2001;76:1–9
  9. Lee JC, Lim KT, Jang YS. Identification of Rhus verniciflua stokes compounds that exhibit free radical scavenging and anti-apoptotic properties. Biochim Biophys Acta. 2002;1570:181–191
  10. Magaudda L, Mondello MR, Vaccaro M, Pergolizzi S, Cannavò SP, Guarneri B, et al. Changes in the distribution of actin-associated proteins in psoriatic keratinocytes. Immunohistochemical study using confocal laser scanning microscopy. Arch Dermatol Res. 1997;289:378–383
  11. Malinda KM, Kleinman HK. The laminins. Int J Biochem Cell Biol. 1996;28:957–959
  12. Mankarios AT, Jones CFG, Jarvis MC, Thelfall DR, Friend J. Hydrolysis of plant polysaccharides and GLC analysis of their constituent neutral sugars. Phytochemistry. 1979;18:419–422
  13. McGarvie D, Parolis H. Methylation analysis of the mucilage of Opuntia ficus-indica. Carbohyd Res. 1981;88:305–314
  14. Medina-Torres L, Brito-De La Fuente E, Torrestiana-Sanchez B, Katthain R. Rheological properties of the mucilage gum (Opuntia ficus-indica). Food Hydrocolloids. 2000;14:417–424
  15. Medina-Torres L, Brito-De La Fuente E, Torrestiana-Sanchez B, Alonso S. Mechanical properties of gels formed by mixtures of mucilage gum (Opuntia ficus-indica) and carrageenans. Carbohyd Polym. 2003;52:143–150
  16. Mondello MR, Magaudda L, Pergolizzi S, Santoro A, Vaccaro M, Califano L, et al. Behaviour of lamin 1 and type IV collagen in uninvolved psoriatic skin. Immunohistochemical study using confocal laser scanning microscopy. Arch Dermatol Res. 1996;288:527–531
  17. Moulin V, Auger FA, Garrel D, Germain L. Role of wound healing myofibroblasts on re-epithelialization of human skin. Burns. 2000;26:3–12
  18. Mutsaers SE, Bishop JE, McGrouther G, Laurent GJ. Mechanisms of tissue repair: from wound healing to fibrosis. Int J Biochem Cell Biol. 1997;29:5–17
  19. Nguyen BP, Ryan MC, Gil SG, Carter WG. Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion. Curr Opin Cell Biol. 2000;12:554–562
  20. Nishiyama T, Amano S, Burgeson RE. Structure and molecular assembly of the dermal–epidermal attachment complex in skin. Connect Tissue. 1998;30:213–217
  21. Nishiyama T, Amano S, Tsunenaga M, Kadoya K, Takeda A, Adachi E, et al. The importance of laminin 5 in the dermal-epidermal basement membrane. J Dermatol Sci. 2000;24(Suppl 1):S51–S59
  22. Park EH, Chun MJ. Wound healing of Opuntia ficus-indica. Fitoterapia. 2001;72:165–167
  23. Pimienta-Barrios E. El nopal tunero (Primera Edicìon). Mèxico: Universidad de Guadalajara; 1991;
  24. Raimondi L, Banchelli G, Dalmazzi D, Mulinacci N, Romani A, Vincieri FF, et al. Sedum telephium L. polysaccharide content affects MRC5 cell adhesion to laminin and fibronectin. J Pharm Pharmacol. 2000;52:585–591
  25. Saliba MJ. Heparin in the treatment of burns: a review. Burns. 2001;27:349–358
  26. Sato N, Nakamura M, Chikama T, Nishida T. Abnormal deposition of laminin and type IV collagen at corneal epithelial basement membrane during wound healing in diabetics rats. Jpn J Ophthalmol. 1999;43:343–347
  27. Schaffer CJ, Nanney LB. Cell biology of wound healing. Int Rev Cytol. 1996;169:151–181
  28. Schmidgall J, Schnetz E, Hensel A. Evidence for bioadhesive effects of polysaccharides and polysaccharide-containing herbs in an ex vivo bioadhesion assay on buccal membranes. Planta Med. 2000;66:48–53
  29. Sendl A, Mulinacci N, Vincieri FF, Wagner H. Anti-inflammatory and immunologically active polysaccharides of Sedum telephium. Phytochemistry. 1993;34:1357–1362
  30. Strickland FM. Immune regulation by polysaccharides: implications for skin cancer. J Photochem Photobiol B: Biol. 2001;63:132–140
  31. Tomoda M, Matsumoto K, Shimizu N, Gonda E, Ohara N, Hirabayashi K. An acidic polysaccharide with immunological activities from the root of Paeonia lactiflora. Biol Pharm Bull. 1994;17:1161–1164
  32. Trachtenberg S, Mayer AM. Biophysical properties of Opuntia ficus-indica mucilage. Phytochemistry. 1982;21:2835–2843
  33. Tramontina VA, Machado MA, Nogueira Filho Gda R, Kim SH, Vizzioli MR, Toledo S. Effect of bismuth subgallate (local hemostatic agent) on wound healing in rats. Histological and histometric findings. Braz Dent J. 2002;13:11–16

PII: S0944-7113(05)00153-4

doi: 10.1016/j.phymed.2005.06.006

Phytomedicine
Volume 13, Issue 5 , Pages 352-358 , 9 May 2006