Phytomedicine
Volume 13, Issue 5 , Pages 334-342 , 9 May 2006

Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in

  • H. Tanabe

      Affiliations

    • Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan
    • ,
  • H. Suzuki

      Affiliations

    • Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan
    • ,
  • A. Nagatsu

      Affiliations

    • Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan
    • ,
  • H. Mizukami

      Affiliations

    • Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan
    • ,
  • Y. Ogihara

      Affiliations

    • Laboratory of Kampo Medicine, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku-ku, Nagoya 468-8503, Japan
    • ,
  • M. Inoue

      Affiliations

    • Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan
    • Corresponding Author InformationCorresponding author. Tel./fax: +81528363415.

References 

  1. Alcocer F, Whitley D, Salazar-Gonzalez JF, Jordan WD, Sellers MT, Eckhoff DE, et al. Quercetin inhibits human vascular smooth muscle cell proliferation and migration. Surgery. 2002;131:198–204
  2. Chang YL, Usami S, Hsieh MT, Jiang MJ. Effects of palmatine on isometric force and intracellular calcium levels of arterial smooth muscle. Life Sci. 1999;64:597–606
  3. Colombo ML, Bugatti C, Mossa A, Pescalli N, Piazzoni L, Pezzoni G, et al. Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine. Farmaco. 2001;56:403–409
  4. Cushman M, Dekow FW, Jacobsen LB. Conformations, DNA binding parameters, and antileukemic activity of certain cytotoxic protoberberine alkaloids. J. Med. Chem. 1979;22:331–333
  5. Ferri N, Yokoyama K, Sadilek M, Paoletti R, Apitz-Castro R, Gelb MH, et al. Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation. Br. J. Pharmacol. 2003;138:811–818
  6. Hattori T, Furuta K, Nagao T, Nagamatsu T, Ito M, Suzuki Y. Studies on the antinephritic effect of plant components (4): Reduction of protein excretion by berberine and coptisine in rats with original-type anti-GBM nephritis. Jpn. J. Pharmacol. 1992;59:159–169
  7. Hikiami H, Kohta K, Sekiya N, Shimada Y, Itoh T, Terasawa K. Erythrocyte deformability in “oketsu” syndrome and its relation to erythrocyte viscoelasticity. J. Trad. Med. 1996;13:156–164
  8. Hirano H, Osawa E, Yamaoka Y, Yokoi T. Gastric-mucous membrane protection activity of coptisine derivatives. Biol. Pharm. Bull. 2001;24:1277–1281
  9. Hu JP, Takahashi N, Yamada T. Coptidis rhizoma inhibits growth and proteases of oral bacteria. Oral Dis. 2000;6:297–302
  10. Iizuka N, Miyamoto K, Okita K, Tangoku A, Hayashi H, Yosino S, et al. Inhibitory effect of Coptidis rhizoma and berberine on the proliferation of human esophageal cancer cell lines. Cancer Lett. 2000;148:19–25
  11. Iizuka N, Miyamoto K, Hazama S, Yoshino S, Yoshimura K, Okita K, et al. Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6. Cancer Lett. 2000;158:35–41
  12. Kase Y, Saitoh K, Makino B, Hashimoto K, Ishige A, Komatsu Y. Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active components. Phytother. Res. 1999;13:468–473
  13. Ko WH, Yao XQ, Lau CW, Law WI, Chen ZY, Kwok W, et al. Vasorelaxant and antiproliferative effects of berberine. Eur. J. Pharmacol. 2000;399:187–196
  14. Kobayashi S, Mimura Y, Notoya K, Kimura I, Kimura M. Antiproliferative effects of the traditional Chinese medicine Shimotsu-to, its component cnidium rhizoma and derived compounds on primary cultures of mouse aorta smooth muscle cells. Jpn. J. Pharmcol. 1992;60:397–401
  15. Kohta K, Hiyama Y, Terasawa K, Hamazaki T, Itoh T, Tosa H. Hemorrheological studies of “oketsu” syndrome – Erythrocyte aggregation in “oketsu” syndrome. J. Med. Pharm. Soc. WAKAN-YAKU. 1992;9:221–228
  16. Lin CC, Ng LT, Hsu FF, Shieh DE, Chiang LC. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine, and icariin) on hepatoma and leukaemia cell growth. Clin. Exp. Pharmacol. Physiol. 2004;31:65–69
  17. Mack CP, Thompson MM, Lawrenz-Smith S, Owens GK. Smooth muscle α-actin CArG elements coordinate formation of a smooth muscle cell-selective, serum response factor-containing activation complex. Circ. Res. 2000;86:221–232
  18. Nandi R, Debnath D, Maiti M. Interactions of berberine with poly(A) and tRNA. Biochim. Biophys. Acta. 1990;1049:339–342
  19. Ro JS, Lee SS, Lee KS, Lee MK. Inhibition of type A monoamine oxidase by coptisine in mouse brain. Life Sci. 2001;70:639–645
  20. Ross R. Atherosclerosis – an inflammatory disease. N. Engl. J. Med. 1999;340:115–126
  21. Shin JS, Kim EI, Kai M, Lee MK. Inhibition of dopamine biosynthesis by protoberberine alkaloids in PC12 cells. Neurochem. Res. 2000;25:363–368
  22. Takase H, Imanishi K, Miura O, Yumioka E, Watanabe H. Features of the anti-ulcer effects of Oren-gedoku-to (a traditional Chinese medicine) and its component herb drugs. Jpn. J. Pharmacol. 1989;49:301–308
  23. Tanaka T, Metori K, Mineo S, Hirotani M, Furuya T, Kobayashi S. Inhibitory effects of berberine-type alkaloids on elastase. Planta Med. 1993;59:200–202
  24. Terasawa K, Toriizuka K, Tosa H, Ueno M, Hayashi T, Shimizu M. Rheological studies on “oketsu” syndrome I. The blood viscosity and diagnostic criteria. J. Med. Pharm. Soc. WAKAN-YAKU. 1986;3:98–104
  25. Yakazu D. Considerations on Oketsu (stagnation of disordered blood), one of the cardinal pathogenetic factors in oriental medicine. J. Japan Soc. Oriental Med. 1975;25:167–187
  26. Zhan YH, Fang LH, Ku BS. Fangchinoline inhibits rat aortic vascular smooth muscle cell proliferation and cell cycle progression through inhibition of ERK1/2 activation and c-fos expression. Biochem. Pharmacol. 2003;66:1853–1860

PII: S0944-7113(05)00170-4

doi: 10.1016/j.phymed.2005.02.001

Phytomedicine
Volume 13, Issue 5 , Pages 334-342 , 9 May 2006

Article Tools

* Image Usage & Resolution