Phytomedicine
Volume 13, Issue 5 , Pages 359-365 , 9 May 2006

Induction of apoptosis by carbazole alkaloids isolated from Murraya koenigii

  • C. Ito

      Affiliations

    • Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan
    • ,
  • M. Itoigawa

      Affiliations

    • Tokai Gakuen University, Nagoya, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81528011201; fax: +81528041044.
    • ,
  • K. Nakao

      Affiliations

    • Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan
    • ,
  • T. Murata

      Affiliations

    • Department of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan
    • ,
  • M. Tsuboi

      Affiliations

    • Department of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan
    • ,
  • N. Kaneda

      Affiliations

    • Department of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan
    • ,
  • H. Furukawa

      Affiliations

    • Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan

Received 27 September 2004 ,Accepted 9 March 2005.

References 

  1. Hirano T, Oka K, Mimaki Y, Kuroda M, Sashida Y. Potent growth inhibitory activity of a novel Ornithogalum cholestane glycoside on human cells: induction of apoptosis in promyelocytic leukemia HL-60 cells. Life Sci. 1996;58:789–798
  2. Ito C, Furukawa H. Three new coumarins from Murraya exotica. Heterocycles. 1987;26:1731–1734
  3. Ito C, Furukawa H. Three new coumarins from leaves of Murraya paniculata. Heterocycles. 1987;26:2959–2962
  4. Ito C, Nakagawa M, Wu T-S, Furukawa H. New carbazole alkaloids from Murraya euchrestifolia. Chem. Pharm. Bull. 1991;39:1668–1671
  5. Ito C, Thoyama Y, Omura M, Kajiura I, Furukawa H. Alkaloidal constituents of Murraya koenigii. Isolation and structural elucidation of novel binary carbazolequinones and carbazole alkaloids. Chem. Pharm. Bull. 1993;41:2096–2100
  6. Itoigawa M, Kashiwada Y, Ito C, Furukawa H, Tachibana Y, Bastow KF, et al. Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents. J. Nat. Prod. 2000;63:893–897
  7. Kan, W.S., 1972. Manual of Medicinal Plants in Taiwan, vol. 2. National Research Institute of Chinese Medicine, Taiwan, pp. 377–378
  8. Nagashima F, Kondoh M, Uematsu T, Nishiyama A, Saito S, Sato M, et al. Cytotoxic and apoptosis-inducing ent-kaurane-type diterpenoids from the Japanese liverwort Jungermannia truncata Nees. Chem. Pharm. Bull. 2002;50:808–813
  9. Nakahara K, Trakoontivakorn G, Alzoreky NS, Ono H, Onishi-Kameyama M, Yoshida M. Antimutagenicity of some edible Thai plants, and a bioactive carbazole alkaloid, mahanine, isolated from Micromelum minutum. J. Agric. Food Chem. 2002;50:4796–4802
  10. Patel T, Gores GJ, Kaufmann SH. The role of proteases during apoptosis. FASEB J. 1996;10:587–597
  11. Ramsewak RS, Nair MG, Strasburg GM, DeWitt DL, Nitiss JL. Biologically active carbazole alkaloids from Murraya koenigii. J. Agric. Food Chem. 1999;47:444–447
  12. Tachibana Y, Kikuzaki H, Lajis NH, Nakatani N. Antioxidative activity of carbazoles from Murraya koenigii leaves. J. Agric. Food Chem. 2001;49:5589–5594
  13. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev. 2001;15:2922–2933
  14. Wang IK, Lin-Shiau SY, Lin JK. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur. J. Cancer. 1999;35:1517–1525
  15. Zhu XF, Liu ZC, Xie BF, Li ZM, Feng GK, Xie HH, et al. Involvement of caspase-3 activation in squamocin-induced apoptosis in leukemia cell line HL-60. Life Sci. 2002;70:1259–1269

PII: S0944-7113(05)00172-8

doi: 10.1016/j.phymed.2005.03.010

Phytomedicine
Volume 13, Issue 5 , Pages 359-365 , 9 May 2006

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