Phytomedicine
Volume 13, Issue 9 , Pages 728-731 , 24 November 2006

Effects of Leontice smirnowii tuber monodesmosides and crude extract in carrageenan- and histamine-induced acute inflammation model of rats

  • A. Gepdiremen

      Affiliations

    • Faculty of Medicine, Department of Pharmacology, Ondokuz Mayıs University, TR-55139-Kurupelit Samsun, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +9036231219192294; fax: +903624576041.
    • ,
  • V. Mshvildadze

      Affiliations

    • Institue of Pharmacochemistry, Academy of Sciences of Georgia 36, st. P. Sarajishvili, 380059-Tbilisi, Goergia
    • ,
  • K. Bakuridze

      Affiliations

    • Department of Pharmacology, Tbilisi State Medical University, P. Sarajishvili, Tbilisi, Georgia
    • ,
  • R. Elias

      Affiliations

    • Laboratory of Pharmacognosy and Homeopathy, Pharmacy Faculty of Mediterranean University, 13385 Marseille, France

References 

  1. Antonio MA, Souza Brito AR. Oral anti-inflammatory and anti-ulcerogenic activities of a hydroalcoholic extract and partitioned fractions of Turnera ulmifolia. J. Ethnopharmacol. 1998;61:215–228
  2. Birch PJ, Harrison SM, Hayes AG, Rogers H, Tyers MB. The non-peptide NK1 receptor antagonist, (+/−)-CP-96,345, produces antinociceptive and anti-edema effects in the rat. Br. J. Pharmacol. 1992;105:508–510
  3. Choi J, Huh K, Kim SH, Lee KT, Park HJ, Han YN. Antinociceptive and anti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals. J. Ethnopharmacol. 2002;792:199–204
  4. Choi J, Huh K, Kim SH, Lee KT, Lee HK, Park HJ. Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent. J. Ethnopharmacol. 2002;79:113–118
  5. Gepdiremen A, Mshvildadze V, Süleyman H, Elias R. Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema. Phytomedicine. 2005;12:440–444
  6. Goodman-Gilman A. In:  Hardman JG,  Limbird LE editor. The Pharmacological Basis of Theraputics. 10th ed. USA: McGraw Medical Publishing Division; 1990;p. 575–582
  7. Gülçin, İ., Mshvildadze, V., Gepdiremen, A., Elias, R., in press. Screening of antiradical and antioxidant activity of monodesmosides and crude extract from Leontice smirnowii tuber. Phytomedicine.
  8. Kim YK, Kim RG, Park SJ, Ha JH, Choi JW, Park HJ, et al. In vitro antiinflammatory activity of kalopanaxsaponin A isolated from Kalopanax pictus in murine macrophage RAW 264.7 cells. Biol. Pharmaceut. Bull. 2002;25:472–476
  9. Li da W, Hyun JE, Jeong CS, Kim YS, Lee EB. Antiinflammatory activity of alpha-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract. Biol. Pharmaceut. Bull. 2003;26:429–433
  10. Liu Q, Zhu G, Huang P. Anti-inflammatory, analgesic and sedative effects of Leontice kiangnanensis P.L. Chiu. Zhongguo Zhong Yao Za Zhi. 1991;161:50–53
  11. Verpoorte R. Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development. Drug Discov. Today. 1999;3:232–238
  12. Vinegar R, Truax JF, Selph JH, Johnsstone PR, Venable AL, Mckenzie KK. Pathway to carrageenan-induced inflammation in the hind limb of the rat. Fed. Proc. 1987;6:118–126

PII: S0944-7113(05)00219-9

doi: 10.1016/j.phymed.2005.09.011

Phytomedicine
Volume 13, Issue 9 , Pages 728-731 , 24 November 2006

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