Phytomedicine
Volume 13, Issue 9 , Pages 732-734 , 24 November 2006

Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines

  • L. Delmulle

      Affiliations

    • Ghent University-UGent, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, B-9000 Ghent, Belgium
    • ,
  • A. Bellahcène

      Affiliations

    • Metastasis Research Laboratory, University of Liège, B-4000 Liège, Belgium
    • ,
  • W. Dhooge

      Affiliations

    • Ghent University Hospital, Department of Endocrinology, B-9000 Ghent, Belgium
    • ,
  • F. Comhaire

      Affiliations

    • Ghent University Hospital, Department of Endocrinology, B-9000 Ghent, Belgium
    • ,
  • F. Roelens

      Affiliations

    • Ghent University-UGent, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, B-9000 Ghent, Belgium
    • ,
  • K. Huvaere

      Affiliations

    • Ghent University-UGent, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, B-9000 Ghent, Belgium
    • ,
  • A. Heyerick

      Affiliations

    • Ghent University-UGent, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, B-9000 Ghent, Belgium
    • ,
  • V. Castronovo

      Affiliations

    • Metastasis Research Laboratory, University of Liège, B-4000 Liège, Belgium
    • ,
  • D. De Keukeleire

      Affiliations

    • Ghent University-UGent, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, B-9000 Ghent, Belgium
    • Corresponding Author InformationCorresponding author. Tel.: +3292648055; fax: +3292648192.

References 

  1. De Vincenzo R, Scambia G, Benedetti Panici P, Ranelletti FO, Bonanno G, Ercoli A, et al. Effect of synthetic and naturally occurring chalcones on ovarian cancer cell growth: structural–activity relationships. Anticancer Drug Res. 1995;10:481–490
  2. Gerhaeuser C, Alt A, Heiss E, Gamal-Eldeen A, Klimo K, Knauft J, et al. Cancer chemopreventive activity of xanthohumol, a natural product derived from hop. Mol. Cancer Ther. 2002;1:959–969
  3. Lau K-M, LaSpina M, Long J, Ho S-M. Expression of oestrogen receptor (ER)-α and ER-β in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation. Cancer Res. 2000;60:3175–3182
  4. Maruyama S, Fujimoto N, Asano K, Ito A, Usui T. Expression of oestrogen receptor alpha and beta mRNAs in prostate cancer treated with leuprorelin acetate. Eur. Urol. 2000;38:635–639
  5. Milligan SR, Kalita JC, Heyerick A, Rong H, De Cooman L, De Keukeleire D. Identification of a potent phytooestrogen in hops (Humulus lupulus L.) and beer. J. Clin. Endocrinol. Metab. 1999;83:2249–2252
  6. Miranda CL, Stevens JF, Helmrich A, Henderson MC, Rodriguez RJ, Yang YH, et al. Anti-proliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food Chem. Toxicol. 1999;37:271–285
  7. Stevens JF, Ivançic M, Hsu VL, Deinzer ML. Prenylflavonoids from Humulus lupulus. Phytochemistry. 1997;44:1575–1585
  8. Stevens JF, Taylor AW, Clawson JE, Deinzer ML. Fate of xanthohumol and related prenylflavonoids from hops to beer. J. Agric. Food Chem. 1999;47:2421–2428
  9. Yit CC, Das NP. Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. Cancer Lett. 1994;82:65–72
  10. Zierau O, Gester S, Schwab P, Metz P, Kolba S, Wulf M, et al. Estrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin. Planta Med. 2002;68:449–451

PII: S0944-7113(06)00012-2

doi: 10.1016/j.phymed.2006.01.001

Phytomedicine
Volume 13, Issue 9 , Pages 732-734 , 24 November 2006

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