Phytomedicine
Volume 13, Issue 5 , Pages 371-377 , 9 May 2006

A systematic review of randomised clinical trials of Tripterygium wilfordii for rheumatoid arthritis

  • P.H. Canter

      Affiliations

    • Complementary Medicine, Peninsula Medical School, Universities of Exeter & Plymouth, 25 Victoria Park Rd, Exeter, Devon EX2 4NT, UK
    • Corresponding Author InformationCorresponding author. Tel.: +441392439035; fax: +441392424989.
  • ,
  • Hyang Sook Lee

      Affiliations

    • Department of Meridianology, College of Oriental Medicine, SangJi University, Wonju, Korea
  • ,
  • E. Ernst

      Affiliations

    • Complementary Medicine, Peninsula Medical School, Universities of Exeter & Plymouth, 25 Victoria Park Rd, Exeter, Devon EX2 4NT, UK

References 

  1. Asano K, Matsuishi J, Yu Y, Kasahara T, Hisamitsu T. Suppressive effects of Tripterygium wilfordii Hook F., a traditional Chinese medicine, on collagen arthritis in mice. Immunopharmacology. 1998;39(2):117–126
  2. Chan WY, Ng TB. Adverse effect of Tripterygium wilfordii extract on mouse embryonic development. Contraception. 1995;51(1):65–71
  3. Chang ML, Yang LL, Chang DM, Kuo SY, Chu SJ. [The influence of Chinese traditional medicine on the production and activity of interleukin 1 (IL-1)]. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1993;26(1):15–24
  4. Chang DM, Chang WY, Kuo SY, Chang ML. The effects of traditional antirheumatic herbal medicines on immune response cells. J. Rheumatol. 1997;24(3):436–441
  5. Chou WC, Wu CC, Yang PC, Lee YT. Hypovolemic shock and mortality after ingestion of Tripterygium wilfordii Hook F.: a case report. Int. J. Cardiol. 1995;49(2):173–177
  6. Cibere J, Deng Z, Lin Y, Ou R, He Y, Wang Z, et al. A randomized double blind, placebo controlled trial of topical Tripterygium wilfordii in rheumatoid arthritis: reanalysis using logistic regression analysis. J. Rheumatol. 2003;30(3):465–467
  7. Deng Z, Lin Y, Ou R, He Y, Wang Z. A further study on compound Tripterygium wilfordii Hook film in treating rheumatoid arthritis at active stage. J. Guangzhou Univ. Tradit. Chin Med. 1998;15:180–183
  8. Du X, Zhang H, Fu X. [Clinical study on Tripterygium wilfordii complex ester tablet in treating rheumatoid arthritis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998;18(2):88–91
  9. Gu CX. [Cause of amenorrhea after treatment with Tripterygium wilfordii F.]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1989;11(2):151–153
  10. Guo JL, Yuan SX, Wang XC, Xu SX, Li DD. Tripterygium wilfordii Hook in rheumatoid arthritis and ankylosing spondylitis. Preliminary report. Chin. Med. J. 1981;94:405–412
  11. Ho LJ, Chang DM, Chang ML, Kuo SY, Lai JH. Mechanism of immunosuppression of the antirheumatic herb TWHf in human T cells. J. Rheumatol. 1999;26(1):14–24
  12. Huang, Cf., Wu, C.B., Shen, Z.K., 1989. Study on the treatment of rheumatoid arthritis with polyglycosides of Tripterygium wilfordii Hook F.; a randomized, controlled, crossover clinical trial. In: Proceedings of the Third National Meeting of Rheumatology of China, Shiji-azhuang, China, 1989. Chinese Association of Medicine, Beijing, China, 1989, pp. 31–33.
  13. Jadad AR, Moore RA, Carrol D, Jenkinson C, Reynolds DJM, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Contrib. Clin. Trials. 1996;17:1–12
  14. Ji H, Yao S, Luo Q, Cao X. TCM treatment of rheumatoid arthritis by supplementing the kidney and invigorating the blood circulation. J. Tradit. Chin. Med. 2002;22(4):252–255
  15. Jiang L, Zhao N, Ni L. Retrospective study of adverse events in patients with rheumatoid arthritis treated with second-line drugs. Zhonghua Liu Xing Bing Xue Za Zhi. 2002;23(3):213–217
  16. Li RL, Liu PL, Wu XC. [Clinical and experimental study on sustained release tablet of Tripterygium wilfordii in treating rheumatoid arthritis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996;16(1):10–13
  17. Little CV, Parsons T. Herbal therapy for treating rheumatoid arthritis. Cochrane Database Syst. Rev. 2000;(4):
  18. Pyatt DW, Yang Y, Mehos B, Le A, Stillman W, Irons RD. Hematotoxicity of the Chinese herbal medicine Tripterygium wilfordii Hook F. in CD34-positive human bone marrow cells. Mol. Pharmacol. 2000;57(3):512–518
  19. Qian SZ. Tripterygium wilfordii, a Chinese herb effective in male fertility regulation. Contraception. 1987;36:335–345
  20. RA Cooperative Group. Clinical trial of Tripterygium wilfordii Hook in the treatment of 31 patients with rheumatoid arthritis. Wu Han Yi Xue Pao. 1977;6:51–53
  21. Resch KL, Hill S, Ernst E. Use of complementary therapies by individuals with ‘arthritis’. Clin. Rheumatol. 1997;16:391–395
  22. Su DF, Li RL, Sun YJ. Comparative study of triptolide and the ethyl acetate extract of Tripterygium wilfordii Hook F. in the treatment of rheumatoid arthritis. Zhong Cao Yao. 1990;10:144–146, 131
  23. Takei A, Nagashima G, Suzuki R, Hokaku H, Takahashi M, Miyo T, et al. Meningoencephalocele associated with Tripterygium wilfordii treatment. Pediatr. Neurosurg. 1997;27(1):45–48
  24. Tao X, Lipsky PE. The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F. Complementary and alternative therapies for rheumatic diseases II. Rheumatic Disease Clinics of North America. 2000;26:29–50
  25. Tao XL, Dong Y, Zhang NZ. [A double-blind study of T2 (tablets of polyglycosides of Tripterygium wilfordii Hook) in the treatment of rheumatoid arthritis]. Zhonghua Nei Ke Za Zhi. 1987;26(7):399–402
  26. Tao XL, Sun Y, Dong Y, Xiao YL, Hu DW, Shi YP. A double blind, controlled trial of Tripterygium wilfordii glycosides in the treatment of rheumatoid arthritis. Arthritis Rheum. 1987;30(Suppl. 5):S59
  27. Tao XL, Sun Y, Dong Y, Xiao YL, Hu DW, Shi YP, et al. A prospective, controlled, double-blind, cross-over study of Tripterygium wilfordii Hook F. in treatment of rheumatoid arthritis. Chin. Med. J. (Engl.). 1989;102(5):327–332
  28. Tao X, Sun Y, Zhang N. [Treatment of rheumatoid arthritis with low doses of multi-glycosides of Tripterygium wilfordii]. Zhong Xi Yi Jie He Za Zhi. 1990;10(5):289–292
  29. Tao X, Schulze-Koops H, Ma L, Cai J, Mao Y, Lipsky PE. Effects of Tripterygium wilfordii Hook F. extracts on induction of cyclooxygenase 2 activity and prostaglandin E2 production. Arthritis Rheum. 1998;41(1):130–138
  30. Tao X, Cush JJ, Garret M, Lipsky PE. A phase I study of ethyl acetate extract of the Chinese antirheumatic herb Tripterygium wilfordii Hook F. in rheumatoid arthritis. J. Rheumatol. 2001;28(10):2160–2167
  31. Tao X, Younger J, Fan FZ, Wang B, Lipsky PE. Benefit of an extract of Tripterygium wilfordii Hook F. in patients with rheumatoid arthritis: a double-blind, placebo-controlled study. Arthritis Rheum. 2002;46(7):1735–1743
  32. Wang ZF, Zhang YH, Huang GZ. An experimental, pathological study of subchronic intoxication of ethyl acetate extract of Tripterygium wilfordii Hook. Tong Ji Yi Ke Da Xue Pao. 1991;20:247–250
  33. Wu YJ, Lao ZY, Zhang ZL. [Clinical observation on small doses Tripterygium wilfordii polyglycoside combined with methotrexate in treating rheumatoid arthritis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(12):895–896
  34. Xu DS, Shen ZY, Lu W. [Clinical and experimental study of RA mixture in treatment of rheumatoid arthritis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996;16(1):14–17, 23
  35. Zhang NZ, et al. A preliminary clinical study of T2 in the treatment of rheumatoid arthritis. Arthritis Rheum. 1981;
  36. Zhen QS, Ye X, Wei ZJ. Recent progress in research on Tripterygium: a male antifertility plant. Contraception. 1995;51(2):121–129
  37. Zheng JR, Liu JH, Xu LF, et al. Studies on toxicity of total glycosides in Tripterygium wilfordii. Acta Acad. Med. Sin. 1983;5:73–78
  38. Zhou J, Zhu Q, Yang X. [Clinical observation of side effects of Tripterygium preparation]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999;19(2):77–79
  39. Zhou X, Zhou Z, Jin M, Wang H, Wu M, Song Y, et al. Clinical study of qingluo tongbi granules in treating 63 patients with rheumatoid arthritis of the type of yin-deficiency and heat in collaterals. J. Tradit. Chin. Med. 2004;24(2):83–87

PII: S0944-7113(06)00022-5

doi: 10.1016/j.phymed.2006.01.010

Phytomedicine
Volume 13, Issue 5 , Pages 371-377 , 9 May 2006