Phytomedicine
Volume 14, Issue 7 , Pages 546-550, 6 August 2007

Inhibitors of aldose reductase and advanced glycation end-products formation from the leaves of Stelechocarpus cauliflorus R.E. Fr.

  • L. Wirasathien

      Affiliations

    • Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    • ,
  • T. Pengsuparp

      Affiliations

    • Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    • ,
  • R. Suttisri

      Affiliations

    • Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    • Corresponding Author InformationCorresponding author. Tel.: +662022188353; fax: +662022188354.
    • ,
  • H. Ueda

      Affiliations

    • Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan
    • ,
  • M. Moriyasu

      Affiliations

    • Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan
    • ,
  • K. Kawanishi

      Affiliations

    • Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan

Abstract 

Two dihydroflavonol glycosides, engeletin and astilbin, were isolated from an EtOAc extract of the leaves of Stelechocarpus cauliflorus R.E. Fr. (Annonaceae). The inhibitory activity of engeletin against a recombinant human aldose reductase (IC50 value=1.16μM) was twice that of quercetin as a positive control (2.48μM), and 23 times greater than that of astilbin (26.7μM). Engeletin inhibited the enzyme uncompetitively. Astilbin was about as potent as the positive control, quercetin, in its inhibition of advanced glycation end-products formation. These flavonoids displayed therapeutic potential in the prevention and treatment of diabetic complications.

Abbreviations: AR, aldose reductase, AGE, advanced glycation end-product

Keywords: Stelechocarpus cauliflorus, Dihydroflavonol glycosides, Diabetes, Aldose reductase, Advanced glycation end-products

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PII: S0944-7113(06)00128-0

doi:10.1016/j.phymed.2006.09.001

Phytomedicine
Volume 14, Issue 7 , Pages 546-550, 6 August 2007

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