Phytomedicine
Volume 14 , Pages 52-59 , 5 March 2007

Extract of Pelargonium sidoides (EPs® 7630) inhibits the interactions of group A-streptococci and host epithelia in vitro

References 

  1. Arroll, B., Kenealy, T., 2005. Antibiotics for the common cold and acute purulent rhinitis. The Cochrane Database of Systematic Reviews. 3: Art. No. CD000247. doi:10.1002/14651858.CD000247.pub2.
  2. Chuchalin AG, Berman B, Lehmacher W. Treatment of acute bronchitis in adults with a Pelargonium sidoides preparation (EPs 7630): a randomized, double-blind, placebo controlled trial. Explore. 2005;1:437–445
  3. Courtney HS, Hasty DL, Dale JB. Molecular mechanisms of adhesion, colonization, and invasion of group A-streptococci. Ann. Med. 2002;34:77–87
  4. Cue D, Dombek P, Lam H, Cleary P. Streptococcus pyogenes serotype M1 encodes multiple pathways for entry into human epithelial cells. Infect. Immun. 1998;66:4593–4601
  5. Del Mar, C.B., Glasziou, P.P., Spinks, A.B., 2004. Antibiotics for sore throat. The Cochrane Database of Systematic Reviews. 2: Art. No. CD000023. doi:10.1002/14651858.CD000023.pub2.
  6. Fahey, T., Smucny, J., Becker, L., Glazier, R., 2004. Antibiotics for acute bronchitis. The Cochrane Database of Systematic Reviews. 4: Art. No. CD000245. doi:10.1002/14651858.CD000245.pub2.
  7. Fluckiger U, Jones KF, Fischetti VA. Immunoglobulins to group A streptococcal surface molecules decrease adherence to and invasion of human pharyngeal cells. Infect. Immun. 1998;66:974–979
  8. Hasty DL, Ofek I, Courtney HS, Doyle R. Multiple adhesins of streptococci. Infect. Immun. 1992;60:2147–2152
  9. Huynh H, Feldt LS. Estimation of the Box correction for degrees of freedom from sample data in the randomized block and split plot designs. J. Educ. Stat. 1976;1:69–82
  10. Jonas D, Engels I, Friedhoff C, Spitzmüller B, Daschner FD, Frank U. Efficiacy of moxifloxacin, trovafloxacin, clinafloxacin, and levofloxacin against intracellular Legionella pneumophila. J. Antimicrob. Chemother. 2001;47:147–152
  11. Kayser O, Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med. 1997;63:508–510
  12. Kayser O, Kolodziej H, Kiderlen F. Immunomodulatory principles of Pelargonium sidoides. Phytother. Res. 2001;15:122–126
  13. Kolodziej H, Kayser O, Radtke OA, Kiderlen AF, Koch E. Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine. 2003;10:18–24
  14. LaPenta D, Rubens C, Chi E, Cleary P. Group A streptococci efficiently invade human respiratory epithelial cells. Proc. Natl. Acad. Sci. USA. 1994;91:12115–12119
  15. Molinari G, Chhatwal GS. Invasion and survival of Streptococcus pyogenes in eukaryotic cells correlates with the source of the clinical isolates. J. Infect. Dis. 1998;177:1600–1607
  16. Molinari G, Rohde M, Guzmán CA, Chhatwal GS. Two distinct pathways for the invasion of Streptococcus pyogenes in non-phagocytic cells. Cell. Microbiol. 2000;2:145–154
  17. Niederman M. Bacterial adherence as a mechanism of airway colonization. Eur. J. Clin. Microbiol. Infect. Dis. 1989;8:15–20
  18. Österlund A, Popa R, Nikkila T, Scheynius A, Engstrand L. Intracellular reservoir of Streptococcus pyogenes in vivo: a possible explanation for recurrent pharyngotonsillitis. Laryngoscope. 1997;107:640–646
  19. Rubens CE, Smith S, Hulse M, Chi EY, van Belle G. Respiratory epithelial cell invasion by group B streptococci. Infect. Immun. 1992;60:5157–5163
  20. Sethman CR, Doyle RJ, Cowan MM. Flow cytometric evaluation of adhesion of Streptococcus pyogenes to epithelial cells. J. Microbiol. Methods. 2002;51:35–42

PII: S0944-7113(06)00193-0

doi: 10.1016/j.phymed.2006.11.018

Phytomedicine
Volume 14 , Pages 52-59 , 5 March 2007