Phytomedicine
Volume 14 , Pages 18-26 , 5 March 2007

In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs® 7630

  • Herbert Kolodziej

      Affiliations

    • Freie Universität Berlin, Institute of Pharmacy, Pharmaceutical Biology, Königin-Luise-Str. 2+4, D-14195 Berlin, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +493083853731; fax: +493083853729.
    • ,
  • Albrecht F. Kiderlen

      Affiliations

    • Robert Koch-Institut, Zelluläre Immunologie P 22, Nordufer 20, D-13353 Berlin, Germany

References 

  1. Biron CA. Interferons α and ß as immune regulators – a new look. Immunity. 2001;41:661–664
  2. Bladt S. Umckaloabo® – Droge der afrikanischen Volksmedizin. Dtsch. Apoth. Ztg. 1977;117:1655–1660
  3. Blochin B, Heger M. Umckaloabo® versus symptomatische Therapie in der Behandlung der Angina catarrhalis. Päd. 2000;6:2–8
  4. Blochin B, Haidvogl M, Heger M. Umckaloabo® im Vergleich mit Acetylcystein bei Kindern mit akuter Bronchitis. Der. Kassenarzt. 1999;49:46–49
  5. Conrad, A., Jung, I., Tioua, D., Lallemand, C., Carrapatoso, F., Engels, I., Daschner, F.D., Frank, U., 2006. Extract of Pelargonium sidoides (EPs® 7630) inhibits the interactions of group A streptococci and host epithelia in-vitro. Phytomedicine, this issue.
  6. Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 1988;141:2407–2412
  7. Dome L, Schuster R. Umckaloabo-eine phytotherapeutische Alternative bei akuter Bronchitis im Kindesalter. Ärztezeitschr. Naturheilv. 1996;37:216–222
  8. Gessani S, Belardelli F. IFN-γ expression in macrophages and its possible biological significance. Cytokine Growth Factor Rev. 1998;9:117–123
  9. Gödecke, T., 2005. Phytochemische und pharmakologische Untersuchungen an Pelargonium sidoides DC. Dissertation, Freie Universität. Berlin.
  10. Golovatiouk A, Chuchalin AG. Wirksamkeit eines Extraktes aus Pelargonium sidoides (EPs® 7630) versus Placebo bei akuter Bronchitis. In:  Schulz V,  Rietbrock N,  Roots I,  Loew D editor. Phytopharmaka VII – Forschung und klinische Anwendung. Darmstadt: Steinkopff-Verlag; 2002;p. 3–12
  11. Haidvogl M, Schuster R, Heger M. Akute Bronchitis im Kindesalter-Multizenter-Studie zur Wirksamkeit und Verträglichkeit des Phytotherapeutikums Umckaloabo®. Z. Phytother. 1996;17:300–313
  12. Heger M, Bereznoy VV. Nicht-streptokokkenbedingte Tonsillopharyngitis bei Kindern: Wirksamkeit eines Extraktes aus Pelargonium sidoides (EPs® 7630) im Vergleich zu Placebo. In:  Schulz V,  Rietbrock N,  Roots I,  Loew D editor. Phytopharmaka VII – Forschung und klinische Anwendung. Darmstadt: Steinkopff-Verlag; 2002;p. 13–25
  13. Heil Ch, Reitermann U. Atemwegs- und HNO-Infektionen: Therapeutische Erfahrungen mit dem Phytotherapeutikum Umckaloabo®. TW. Pädiatrie. 1994;7:523–525
  14. Helmstädter A. Umckaloabo® – Late vindication of a secret remedy. Pharm. Historian. 1996;26:2–4
  15. Hör M, Rimpler H, Heinrich M. Inhibition of intestinal chloride secretion by proanthocyanidins from Guazuma ulmifolia. Planta Med. 1995;61:208–212
  16. Hutchings A. Zulu Medicinal Plants. Pietermaritzburg: Natal University Press; 1996;
  17. Kayser O, Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med. 1997;63:508–510
  18. Kayser O, Kolodziej H, Kiderlen AF. Immunomodulatory principles of Pelargonium sidoides. Phytother. Res. 2001;15:122–126
  19. Kolodziej H. Pelargonium reniforme and Pelargonium sidoides: their botany, chemistry and medicinal use. In:  Lis-Balchin M editors. Geranium and Pelargonium. London: Taylor & Francis; 2002;p. 262–290
  20. Kolodziej H, Kayser O. Pelargonium sidoides DC. – Neueste Erkenntnisse zum Verständnis des Phytotherapeutikums Umckaloabo. Z. Phytother. 1998;19:141–151
  21. Kolodziej H, Kayser O, Gutmann M. Arzneilich verwendete Pelargonien aus Südafrika. Dtsch. Apoth. Ztg. 1995;135:853–864
  22. Kolodziej H, Kayser O, Kiderlen AF, Ito H, Hatano T, Yoshida T, et al. Proanthocyanidins and related compounds: antileishmanial activity and modulatory effects on nitric oxide and tumor necrosis factor-α-release in the murine macrophage-like cell line RAW 264.7. Biol. Pharm. Bull. 2001;24:1016–1021
  23. Kolodziej H, Kayser O, Radtke OA, Kiderlen AF, Koch E. Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine. 2003;10(Suppl. IV):18–24
  24. Kolodziej H, Burmeister A, Trun W, Radtke OA, Kiderlen AF, Ito H, et al. Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells. Bioorg. Med. Chem. 2005;13:6470–6476
  25. Latté KP, Kolodziej H. Antioxidant properties of phenolic compounds from Pelargonium reniforme. J. Agric. Food Chem. 2004;52:4899–4902
  26. Marcucci F, Klein B, Kirchner M, Zawatzky R. Production of high titers of interferon gamma by prestimulated spleen cells. Eur. J. Immunol. 1992;12:787–790
  27. Mocellin S, Panelli MC, Wang E, Nagorsen D, Marincola FM. The dual role of IL-10. Trends Immunol. 2003;24:36–38
  28. Mogensen SC, Virelizier JL. The interferon-macrophage alliance. Interferon. 1987;8:55–84
  29. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 1991;43:109–142
  30. Nathan CF, Hibbs JB. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol. 1991;3:65–70
  31. Nussler AK, Biliar TR. Inflammation, immunoregulation, and inducible nitric oxide synthase. J. Leukocyte Biol. 1993;54:171–178
  32. Radtke OA, Kiderlen AF, Kayser O, Kolodziej H. Gene expression profiles of inducible nitric oxide synthase and cytokines in Leishmania major-infected macrophage-like RAW 264.7 cells treated with gallic acid. Planta Med. 2004;70:924–928
  33. Roach TI, Kiderlen AF, Blackwell JM. Role of inorganic nitrogen oxides and tumor necrosis factor alpha in killing Leishmania donovani amastigotes in gamma interferon-lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains. Infect. Immun. 1991;59:3935–3944
  34. Scholz E. Pflanzliche Gerbstoffe – Pharmakologie und Toxikologie. Dtsch. Apoth. Ztg. 1994;34:3167–3179
  35. Sugawara I. Interleukin-18 (IL-18) and infectious diseases, with special emphasis on diseases induced by intracellular pathogens. Microbes Infect. 2000;2:1257–1263
  36. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen specific adaptive immunity. Annu. Rev. Immunol. 1995;13:251–276
  37. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 2003;3:133–146
  38. Trun W, Kiderlen AF, Kolodziej H. Nitric oxide synthase and cytokines gene expression analyses in Leishmania-infected RAW 264.7 cells treated with an extract of Pelargonium sidoides (EPs® 7630). Phytomedicine. 2006;13:570–575
  39. Van Wyk E, Van Oudtshoorn B, Gericke N. Medicinal Plants of South Africa. Pretoria: Briza Publications; 1997;
  40. Wagner H, Jurcic K. Assays for immunmodulation and effects on mediators of inflammation. In:  Dey PM,  Harborne JB editor. Methods in Plant Biochemistry. vol. 6:London: Academic Press; 1991;p. 195–217
  41. Watt C, Breyer-Brandwyk MG. Medicinal and Poisonous Plants of Southern and Eastern Africa. Edinburgh/London: Livingstone; 1962;pp. 449–455

PII: S0944-7113(06)00195-4

doi: 10.1016/j.phymed.2006.11.020

Phytomedicine
Volume 14 , Pages 18-26 , 5 March 2007

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