Phytomedicine
Volume 14, Supplement 1 , Pages 5-8, 5 March 2007

EPs® 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells

  • W. Beil

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +495115322951; fax: +495115322794.
    • ,
  • P. Kilian

Department of Pharmacology, Hannover Medical University, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany

Abstract 

Helicobacter pylori specifically adheres to gastric host cells, mainly based on carbohydrate-mediated cell–cell interaction. The extract of Pelargonium sidoides roots (EPs® 7630), a South African herbal remedy, is currently used to treat acute bronchitis. EPs® 7630 prevents bacteria from attaching to cell membranes. Therefore, the ability of EPs® 7630 to interfere with H. pylori growth and adhesion to gastric epithelial cells (AGS cells) was tested in vitro. EPs® 7630 inhibited H. pylori growth and with higher potency adhesion to gastric AGS cells. EPs® 7630 (50 and 100μg/ml) reduced bacterial count attached to AGS cells by 77% and 91%, respectively. The results suggest that the mode of action of EPs® 7630 is mainly related to its anti-adhesive activity.

Keywords: Pelargonium sidoides, Helicobacter pylori, Adhesion, Gastric epithelial cells

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PII: S0944-7113(06)00199-1

doi:10.1016/j.phymed.2006.11.024

Phytomedicine
Volume 14, Supplement 1 , Pages 5-8, 5 March 2007

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