Phytomedicine
Volume 14 , Pages 5-8 , 5 March 2007

EPs® 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells

  • W. Beil

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +495115322951; fax: +495115322794.
    • ,
  • P. Kilian

References 

  1. Brown DJ. Extract of Pelargonium sidoides: South African herbal remedy successfully treats acute bronchitis and tonsillopharyngitis. Herbal Gram. 2004;63:17–19
  2. Higuchi K, Arakawa T, Ando K, Fujiwara Y, Uchida T, Kuroki T. Eradication of Helicobacter pylori with a Chinese herbal medicine without emergence of resistant colonies. Am. J. Gastroenterol. 1999;94:1419–1420
  3. Hirmo S, Utt M, Ringner M, Wadström T. Inhibition of heparan sulphate and other glycosaminoglycans binding to Helicobacter pylori by various polysulphated carbohydrates. FEMS Immunol. Med. Microbiol. 1995;10(3–4):301–306
  4. Kayser O, Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med. 1997;63(6):508–510
  5. Kolodziej H, Kayser O, Radtke OA, Kiderlen AF, Koch E. Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine. 2003;10(Suppl. 4):18–24
  6. Lamarque D, Peek RM. Pathogenesis of Helicobacter pylori infection. Helicobacter. 2003;8(Suppl. 1):21–30
  7. Latté KP, Kayser O, Tan N, Kaloga M, Kolodziej H. Unusual coumarin patterns of Pelargonium species forming the origin of the traditional herbal medicine umckaloabo. Z. Naturfosch. 2000;55c:528–533
  8. Lee JH, Park EK, Uhm C-S, Chung M-S, Kim KH. Inhibition of Helicobacter pylori adhesion to human gastric adenocarcinoma epithelial cells by acidic polysaccharides from Artemisia capillaris and Panax ginseng. Planta Med. 2004;70:615–619
  9. Li Y, Xu C, Zhang Q, Liu JY, Tan RX. In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases. J. Ethnopharmacol. 2005;98(3):329–333
  10. Marshall B, Warren JR. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;i:1273–1275
  11. Mégraud F, Trimoulet P, Lamouliatte H, Boyanova L. Bactericidal effect of amoxicillin on Helicobacter pylori in an in vitro model using epithelial cells. Antimicrob. Agents Chemother. 1991;35(5):869–872
  12. Meyer JM, Silliman NP, Wang W, Siepman NY, Sugg JE, Morris D, et al. Risk factors for Helicobacter pylori resistance in the United States: the surveillance of H. pylori antimicrobial resistance partnership (SHARP) study, 1993–1999. Ann. Intern. Med. 2002;136(1):13–24
  13. Perri F, Villani MR, Festa V, Quitadamo M, Andriulli A. Predictors of failure of Helicobacter pylori eradication with the standard ‘Maastricht triple therapy’. Aliment. Pharmacol. Ther. 2001;15(7):1023–1029
  14. Ruiz-Bustos E, Ochoa JL, Wadström T, Ascencio F. Isolation and characterisation of putative adhesins from Helicobacter pylori with affinity for heparan sulphate proteoglycan. J. Med. Microbiol. 2001;50:215–222
  15. Simon PM, Goode PL, Mobasseri A, Zopf D. Inhibition of Helicobacter pylori binding to gastrointestinal epithelial cells by sialic acid-containing oligosaccharides. Infect. Immun. 1997;65(2):750–757
  16. Takashima J, Chiba N, Yoneda K, Ohsaki A. Derrisin, a new rotenoid from Derris malaccensis plain and anti-Helicobacter pylori activity of its related constituents. J. Nat. Prod. 2002;65:611–613
  17. Tominaga K, Higuchi K, Hamasaki N, Tanigawa T, Sasaki E, Watanabe T, et al. Antibacterial activity of a Chinese herbal medicine, Gosyuyu (Wu–Chu–Yu) against Helicobacter pylori. Nippon Rinsho. 2005;63(Suppl. 11):592–599
  18. van Amsterdam K, van Vliet AH, Kusters JG, van der Ende A. Of microbe and man: determinants of Helicobacter pylori-related diseases. FEMS Microbiol. Rev. 2006;30(1):131–156
  19. van der Hulst R, Keller JJ, Rauwas EA, Tytgat GN. Treatment of Helicobacter pylori infection: a review of the world literature. Helicobacter. 1996;1:6–19
  20. Wagner S, Beil. W, Westermann J, Logan RP, Bock CT, Trautwein C, et al. Regulation of gastric epithelial cell growth by Helicobacter pylori: evidence for a major role of apoptosis. Gastroenterology. 1997;113:1836–1847

PII: S0944-7113(06)00199-1

doi: 10.1016/j.phymed.2006.11.024

Phytomedicine
Volume 14 , Pages 5-8 , 5 March 2007

Article Tools

* Image Usage & Resolution