Phytomedicine
Volume 14 , Pages 40-45 , 5 March 2007

Treatment of rats with the Pelargonium sidoides extract EPs® 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin

  • E. Koch

      Affiliations

    • Preclinical Research, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +4907214005356; fax: +4907214005150.
  • ,
  • A. Biber

      Affiliations

    • Analytical Development, Deutsche Homöopathie Union, Karlsruhe, Germany

References 

  1. Anonymous. Was ist dran an Umckaloabo?. Arznei-Telegramm. 2003;34:28–29
  2. Bogaards JJ, Bertrand M, Jackson P, Oudshoorn MJ, Weaver RJ, van Bladeren PJ, et al. Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica. 2000;30:1131–1152
  3. Kaminsky LS, Zhang ZY. Human P450 metabolism of warfarin. Pharmacol. Ther. 1997;73:67–74
  4. Kolodziej H, Schulz V. Umckaloabo. Dts. Apoth. Ztg. 2003;143:55–64
  5. Kolodziej H, Kayser O, Radtke OA, Kiderlen AF, Koch E. Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine. 2003;10(Suppl. IV):18–24
  6. Latté KP, Kayser O, Tan N, Kaloga M, Kolodziej H. Unusual coumarin pattern of Pelargonium species forming the origin of the traditional herbal medicine Umckaloabo. Z. Naturforsch. 2000;55c:528–533
  7. Majerus PW, Tollefsen DM. Anticoagulant, thrombolytic, and antiplatelet drugs. In:  Hardman JG,  Limbird LE editor. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York: McGraw-Hill; 2001;p. 1519–1538
  8. Suttcliffe FA, MacNicoll AD, Gibson GG. Aspects of anticoagulant action: a review of the pharmacology, metabolism and toxicology of warfarin and congeners. Drug Metabol. Drug Interact. 1987;5:225–272
  9. Van Sittert NJ, Tuinman CP. Coumarin derivatives (rodenticides). Toxicology. 1994;91:71–76
  10. Wittkowsky A., 2002. Warfarin and its potential interactions with traditional drugs and botanical agents. 〈http://www.pshp.org/ce_files/adis_anticoag.html〉. Accessed on 24.10.2003.
  11. Zimmermann W. Über die gerinnungshemmende Wirkung der Umckaloabo®-Droge. Ärztl. Forsch. 1965;19:278–280

PII: S0944-7113(06)00201-7

doi: 10.1016/j.phymed.2006.11.026

Phytomedicine
Volume 14 , Pages 40-45 , 5 March 2007