Phytomedicine
Volume 14, Issue 4 , Pages 285-288 , 10 April 2007

An extract of Pelargonium sidoides (EPs 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach

  • N. Wittschier

      Affiliations

    • Institute for Pharmaceutical Biology and Phytochemistry, University of Münster, Hittorfstrasse 56, D-48149 Münster, Germany
    • ,
  • G. Faller

      Affiliations

    • St. Vincentius-Hospital, Institute for Pathology, Südendstraße 37, D-76 137 Karlsruhe, Germany
    • ,
  • A. Hensel

      Affiliations

    • Institute for Pharmaceutical Biology and Phytochemistry, University of Münster, Hittorfstrasse 56, D-48149 Münster, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +492518333380.

Received 21 July 2006 ,Accepted 3 November 2006.

References 

  1. Dorfmüller A, Jung I, Tioua DL, Engels I, Daschner FD, Frank U. Indirekte antibakterielle Wirkmechanismen des Pelargonium-sidoides-Wurzelextraktes EPs7630: Hemmung der Interaktion von A-Streptokokken und HEp-2-Zellen. Zt. Phytother. 2005;26(Suppl.):S6–S7
  2. Falk P, Roth KA, Borén T, Westblom TU, Gordon JI, Normark S. An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage specific tropism in the human gastric epithelium. Proc. Natl. Acad. Sci. USA. 1993;90:2035–2039
  3. Kayser O, Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med. 1997;63:508–510
  4. Kayser O, Kolodziej H, Kiderlen AF. Immunmodulatory principles of Pelargonium sidoids. Phytother. Res. 2001;15:122–126
  5. Koch E, Lanzendörfer-Goossen SH, Wohn C. Stimulation of interferon (INF)-β-synthesis and natural liller (NK) cell activity by an aqueous-ethanolic extract from roots of Pelargonium sidoides (Umckaloabo). Naunyn-Schmiedeberg's Arch. Pharmacol. 2002;365(Suppl. 1):R75;(Abstr. 288)
  6. Kolodziej H. Traditionally used Pelargonium species: chemistry and biological activity of Umckaloabo extracts and their constituents. Curr. Topics Phytochem. 2000;3:77–93
  7. Kolodziej, H., Kayser, O., 1998. Pelargonium sidoides DC. Zt. Phytother. 19, 141–151.
  8. Lengsfeld C, Deters A, Faller G, Hensel A. High molecular weight polysaccharides from black currant seeds inhibit adhesion of Helicobacter pylori to human gastric mucosa. Planta Med. 2004;70:620–626
  9. Lengsfeld C, Titgemeyer F, Faller G, Hensel A. Glycosylated compounds from okra inhibit adhesion of Helicobacter pylori to human gastric mucosa. J. Agric. Food Chem. 2004;52:1495–1503
  10. Odenbreit S. Adherence properties of Helicobacter pylori: impact on pathogenesis and adaption to the host. Int. J. Med. Microbiol. 2005;295:317–324
  11. Seidel V, Taylor PW. In vitro activity of extracts and constituents of Pelargonium against rapidly growing mycobacteria. Int. J. Antimicrob. Agents. 2004;23:613–619

PII: S0944-7113(06)00224-8

doi: 10.1016/j.phymed.2006.12.008

Phytomedicine
Volume 14, Issue 4 , Pages 285-288 , 10 April 2007

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