Phytomedicine
Volume 14, Issue 7 , Pages 556-562 , 6 August 2007

Acute effects of three isoflavone class phytoestrogens and a mycoestrogen on cerebral microcirculation

  • Juan B. Salom

      Affiliations

    • Centro de Investigación, Hospital Universitario ‘La Fe’, Ave. Campanar 21, 46009 Valencia, Spain
    • Departamento de Fisiología, Facultad de Medicina y Odontología, Universidad de Valencia, Ave. Blasco Ibáñez 17, 46010 Valencia, Spain
    • Corresponding Author InformationCorresponding author. Centro de Investigación, Hospital Universitario ‘La Fe’, Ave. Campanar 21, 46009 Valencia, Spain. Tel.:+34963862797; fax: +34961973018.
    • ,
  • María Castelló-Ruiz

      Affiliations

    • Centro de Investigación, Hospital Universitario ‘La Fe’, Ave. Campanar 21, 46009 Valencia, Spain
    • ,
  • Fernando J. Pérez-Asensio

      Affiliations

    • Centro de Investigación, Hospital Universitario ‘La Fe’, Ave. Campanar 21, 46009 Valencia, Spain
    • Present address: Departament de Farmacologia i Toxicologia, Institut d’Investigacions Biomediques de Barcelona—CSIC, IDIBAPS, Rosselló 161, 08036 Barcelona, Spain.
    • ,
  • María C. Burguete

      Affiliations

    • Centro de Investigación, Hospital Universitario ‘La Fe’, Ave. Campanar 21, 46009 Valencia, Spain
    • ,
  • Germán Torregrosa

      Affiliations

    • Centro de Investigación, Hospital Universitario ‘La Fe’, Ave. Campanar 21, 46009 Valencia, Spain
    • Departamento de Fisiología, Facultad de Medicina y Odontología, Universidad de Valencia, Ave. Blasco Ibáñez 17, 46010 Valencia, Spain
    • ,
  • Enrique Alborch

      Affiliations

    • Centro de Investigación, Hospital Universitario ‘La Fe’, Ave. Campanar 21, 46009 Valencia, Spain
    • Departamento de Fisiología, Facultad de Medicina y Odontología, Universidad de Valencia, Ave. Blasco Ibáñez 17, 46010 Valencia, Spain

Received 4 July 2006 ,Accepted 10 October 2006.

References 

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  2. Cassidy A. Potential tissue selectivity of dietary phytoestrogens and estrogens. Curr. Opin. Lipidol. 1999;10:47–52
  3. Chin-Dusting JP, Boak L, Husband A, Nestel PJ. The isoflavone metabolite dehydroequol produces vasodilatation in human resistance arteries via a nitric oxide-dependent mechanism. Atherosclerosis. 2004;176:45–48
  4. Cornwell T, Cohick W, Raskin I. Dietary phytoestrogens and health. Phytochemistry. 2004;65:995–1016
  5. Diekman MA, Green ML. Mycotoxins and reproduction in domestic livestock. J. Anim. Sci. 1992;70:1615–1627
  6. Goldwyn S, Lazinsky A, Wei H. Promotion of health by soy isoflavones: efficacy, benefit and safety concerns. Drug Metabol. Drug Interact. 2000;17:261–289
  7. Li HF, Wang LD, Qu SY. Phytoestrogen genistein decreases contractile response of aortic artery in vitro and arterial blood pressure in vivo. Acta Pharmacol. Sin. 2004;25:313–318
  8. Littleton-Kearney MT, Agnew DM, Traystman RJ, Hurn PD. Effects of estrogen on cerebral blood flow and pial microvasculature in rabbits. Am. J. Physiol. Heart Circ. Physiol. 2000;279:H1208–H1214
  9. Lu KT, Chiou RY, Chen LG, Chen MH, Tseng WT, Hsieh HT, et al. Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation. J. Agric. Food Chem. 2006;54:3126–3131
  10. McCullough LD, Alkayed NJ, Traystman RJ, Williams MJ, Hurn PD. Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke. Stroke. 2001;32:796–802
  11. Mendelsohn ME, Karas RH. Molecular and cellular basis of cardiovascular gender differences. Science. 2005;308:1583–1587
  12. Roof RL, Hall ED. Estrogen-related gender difference in survival rate and cortical blood flow after impact-acceleration head injury in rats. J. Neurotrauma. 2000;17:1155–1169
  13. Salom JB, Burguete MC, Perez-Asensio FJ, Torregrosa G, Alborch E. Relaxant effects of 17-β-estradiol in cerebral arteries through Ca2+ entry inhibition. J. Cereb. Blood Flow Metab. 2001;21:422–429
  14. Simons LA, von Konigsmark M, Simons J, Celermajer DS. Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am. J. Cardiol. 2000;85:1297–1301
  15. Sobey CG, Weiler JM, Boujaoude M, Woodman OL. Effect of short-term phytoestrogen treatment in male rats on nitric oxide-mediated responses of carotid and cerebral arteries: comparison with 17-β-estradiol. J. Pharmacol. Exp. Ther. 2004;310:135–140
  16. Squadrito F, Altavilla D, Morabito N, Crisafulli A, D’Anna R, Corrado F, et al. The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis. 2002;163:339–347
  17. Torregrosa G, Burguete MC, Perez-Asensio FJ, Salom JB, Gil JV, Alborch E. Pharmacological profile of phytoestrogens in cerebral vessels: in vitro study with rabbit basilar artery. Eur. J. Pharmacol. 2003;482:227–234
  18. Van Erp-Baart MA, Brants HA, Kiely M, Mulligan A, Turrini A, Sermoneta C, et al. Isoflavone intake in four different European countries: the VENUS approach. Br. J. Nutr. 2003;89(suppl. 1):S25–S30
  19. Walker HA, Dean TS, Sanders TA, Jackson G, Ritter JM, Chowienczyk PJ. The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17-β-estradiol. Circulation. 2001;103:258–262
  20. Washburn S, Burke GL, Morgan T, Anthony M. Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause. 1999;6:7–13
  21. White RE. Estrogen and vascular function. Vascul. Pharmacol. 2002;38:73–80

PII: S0944-7113(06)00234-0

doi: 10.1016/j.phymed.2006.12.017

Phytomedicine
Volume 14, Issue 7 , Pages 556-562 , 6 August 2007

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