Phytomedicine
Volume 14, Issue 4 , Pages 280-284 , 10 April 2007

Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines

  • E. García Prado

      Affiliations

    • Department of Pharmacology, Faculty of Pharmacy, University of Seville, c/ Profesor García González n. 2, 41012 Seville, Spain
    • ,
  • M.D. García Gimenez

      Affiliations

    • Department of Pharmacology, Faculty of Pharmacy, University of Seville, c/ Profesor García González n. 2, 41012 Seville, Spain
    • ,
  • R. De la Puerta Vázquez

      Affiliations

    • Department of Pharmacology, Faculty of Pharmacy, University of Seville, c/ Profesor García González n. 2, 41012 Seville, Spain
    • ,
  • J.L. Espartero Sánchez

      Affiliations

    • Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Seville, Seville, Spain
    • ,
  • M.T. Sáenz Rodríguez

      Affiliations

    • Department of Pharmacology, Faculty of Pharmacy, University of Seville, c/ Profesor García González n. 2, 41012 Seville, Spain
    • Corresponding Author InformationCorresponding author.

Received 1 March 2006 ,Accepted 7 December 2006.

References 

  1. Aguilar JL, Rojas P, Marcelo A, Plaza A, Bauer R, Reininger E. Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae). J. Ethnopharmacol. 2002;81:271–276
  2. Akesson C, Pero RW, Ivars F. C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo. Phytomedicine. 2003;10:23–33
  3. Aquino R, De Simone F, Vincieri FF, Pizza C. New polyhydroxylated triterpenes from Uncaria tomentosa. J. Nat. Prod. 1990;53:559–564
  4. Bacher N, Tiefenthaler M, Sturm S, Stuppner H, Ausserlechner M, Kofler R. Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells. Br. J. Haematol. 2006;132:615–622
  5. De Matta SM, Monache FD, Ferrari F, Marini-Bettolo GB. Alkaloids and procyanidins of a Uncaria sp. from Peru. Pharmacology. 1976;31:527–535
  6. Ganzera M, Muhannad I, Khan RA, Khan IA. Improved method for determination of oxindole alkaloids Uncaria tomentosa by high performance liquid chromatography. Planta Med. 2001;67:447–450
  7. Heitzman ME, Neto CC, Winiarz E, Vaisberg AJ, Hammond GB. Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae). Phytochemistry. 2005;66:5–29
  8. Kitajima M, Hashimoto K, Yokoya M, Takayama H, Sandoval M, Aimi N. Two new nor-triterpene gycosides from Peruvian “Uña de gato” (Uncaria tomentosa). J. Nat. Prod. 2003;66:320–323
  9. Kitajima M, Yokoya M, Takayama H, Aimi N. Synthesis and absolute configuration of a new 3,4-dihydro-β-carboline-type alkaloid, 3,4-dehydro-5(S)-5-carboxystrictosidine, isolated from Peruvian uña de gato (Uncaria tomentosa). Chem. Pharm. Bull. 2002;50:1376–1378
  10. Laus G, Brössner D, Keplinger K. Alkaloids of peruvian Uncaria tomentosa. Phytochemistry. 1997;45:855–860
  11. Montoro P, Carbone V, Quiroz J, De Simone F, Pizza C. Identification and quantification of comonents in extracts of Uncaria tomentosa by HPLC-ES/MS. Phytochemistry. 2004;15:55–64
  12. Muhammad I, Dunbar DC, Khan RA, Ganzera M, Khan IA. Investigation of Uña de Gato 1,7-Deoxyloganic acid and 15NNMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa. Phytochemistry. 2001;57:781–785
  13. Muhammad I, Khan IA, Fischer NH, Fronczek FR. Two steroisomeric pentacyclic oxindole alkaloids from Uncaria tomentosa: uncarine C and uncarine E. Acta Crystallogr. C. 2001;57:480–482
  14. Muñoz M, Rosso M, Pérez A, Coveñas R, Rosso R, Zamarriego C, et al. The NK1 receptor is involved in the antitumoral actino of L-733,060 and in the mitogenic action of substance P on neuroblastoma and glioma cell lines. Neuropeptides. 2005;39:427–432
  15. Philp RB. Herbal–Drug Interaction and Adverse Effects. An Evidence-based Quick Reference Guide. New York: McGraw-Hill; 2004;pp. 63–65
  16. Sandoval M, Charbonne RM, Okuhama NN. Cat's claw inhibits TNF-alpha production and scavenges free radicals: role in cytoprotection. Free Rad. Biol. Med. 2000;29:71–78
  17. Seki H, Takayama H, Aimi N, Sakai S, Ponglux D. A nuclear manetic resonance study on the eleven stereoisomers of heteroyohimbine-type oxindole alkaloids. Chem. Pharm. Bull. 1993;41(12):2077–2086
  18. Wagner H, Kreutzkamp B, Jurcic K. Die alkaloide von Uncaria tomentosa und ihre phagozytose-steigernde Wirkung. Planta Med. 1985;419–423
  19. Wurm M, Kacani L, Laus G, Keplinger K, Dierich MP. Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation regulating factor. Planta Med. 1998;64:701–704

PII: S0944-7113(06)00244-3

doi: 10.1016/j.phymed.2006.12.023

Phytomedicine
Volume 14, Issue 4 , Pages 280-284 , 10 April 2007

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