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Volume 14, Issue 4, Pages 289-300 (10 April 2007)


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Acetylcholinesterase inhibitors from plants

Pulok K. MukherjeeabCorresponding Author Informationemail address, Venkatesan Kumarb, Mainak Malb, Peter J. Houghtona

Abstract 

Inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, is considered as a promising strategy for the treatment of neurological disorders such as Alzheimer's disease, senile dementia, ataxia and myasthenia gravis. A potential source of AChE inhibitors is certainly provided by the abundance of plants in nature. This article aims to provide a comprehensive literature survey of plants that have been tested for AChE inhibitory activity. Numerous phytoconstituents and promising plant species as AChE inhibitors are being reported in this communication.

a Department of Pharmacy, Pharmacognosy Research Laboratories, Franklin-Wilkins Building, King's College London, 150 Stamford Street, London SE1 9NH, UK

b School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India

Corresponding Author InformationCorresponding author. School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Tel./fax:+913324146046.

PII: S0944-7113(07)00030-X

doi:10.1016/j.phymed.2007.02.002


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