Acetylcholinesterase inhibitors from plants
Abstract
Inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, is considered as a promising strategy for the treatment of neurological disorders such as Alzheimer's disease, senile dementia, ataxia and myasthenia gravis. A potential source of AChE inhibitors is certainly provided by the abundance of plants in nature. This article aims to provide a comprehensive literature survey of plants that have been tested for AChE inhibitory activity. Numerous phytoconstituents and promising plant species as AChE inhibitors are being reported in this communication.
Keywords: Plants, Botanicals, Acetylcholinesterase inhibition, Acetylcholine, Alzheimer's disease
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PII: S0944-7113(07)00030-X
doi:10.1016/j.phymed.2007.02.002
© 2007 Elsevier GmbH. All rights reserved.
