Phytomedicine
Volume 15, Issue 5 , Pages 373-377 , 15 May 2008

Transport of sennosides and sennidines from Cassia angustifolia and Cassia senna across Caco-2 monolayers – an in vitro model for intestinal absorption

  • B. Waltenberger

      Affiliations

    • Department of Pharmacognosy, Institute of Pharmacy, University of Innsbruck, 6020 Innsbruck, Austria
    • ,
  • B. Avula

      Affiliations

    • National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA
    • ,
  • M. Ganzera

      Affiliations

    • Department of Pharmacognosy, Institute of Pharmacy, University of Innsbruck, 6020 Innsbruck, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +435125075307; fax: +435125072939.
    • ,
  • I.A. Khan

      Affiliations

    • National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA
    • ,
  • H. Stuppner

      Affiliations

    • Department of Pharmacognosy, Institute of Pharmacy, University of Innsbruck, 6020 Innsbruck, Austria
    • ,
  • S.I. Khan

      Affiliations

    • National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA

References 

  1. Artursson P, Karlsson J. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Co. 1991;175:880–885
  2. Chong S, Dando SA, Morrison RA. Evaluation of Biocoat® intestinal epithelium differentiation environment (3-day cultured Caco-2 cells) as an absorption screening model with improved productivity. Pharm. Res. 1997;14:1835–1837
  3. Khan SI, Abourashed EA, Khan IA, Walker LA. Transport of parthenolide across human intestinal cells (Caco-2). Planta. Med. 2003;69:1009–1012
  4. Khan SI, Abourashed EA, Khan IA, Walker LA. Transport of harman alkaloids across Caco-2 cell monolayers. Chem. Pharm. Bull. 2004;52:394–397
  5. Krumbiegel G, Schulz HU. Rhein and aloe-emodin kinetics from senna laxatives in man. Pharmacology. 1993;47(Suppl 1):120–124
  6. Laitinen L, Takala E, Vuorela H, Vuorela P, Kaukonen AM, Marvola M. Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2). Eur. J. Pharm. Biopharm. 2007;
  7. Lim SL, Lim LY. Effects of citrus fruit juices on cytotoxicity and drug transport pathways of Caco-2 cell monolayers. Int. J. Pharm. 2006;307:42–50
  8. Raimondi F, Santoro P, Maiuri L, Londai M, Annunziata S, Ciccimarra F, et al. Reactive nitrogen species modulate the effects of rhein, an active component of senna laxatives, on human epithelium in vitro. J. Pedriatr. Gastroenerol. Nutr. 2002;34:529–534
  9. Shah P, Jogani V, Bagchi T, Misra A. Role of Caco-2 cell monolayers in prediction of intestinal drug absorption. Biotechnol. Prog. 2006;22:186–198
  10. Wagner H. Arzneidrogen und ihre Inhaltsstoffe. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 1999;pp. 299–301
  11. Walgren RA, Walle UK, Walle T. Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells. Biochem. Pharmacol. 1998;55:1721–1727
  12. Walle UK, Galijatovic A, Walle T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem. Pharmacol. 1999;58:431–438
  13. Wichtl M. Teedrogen und Phytopharmaka. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2002;pp. 563–571
  14. Yamashita S, Furubayashi T, Kataoka M, Sakane T, Sezaki H, Tokuda H. Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells. Eur. J. Pharm. Sci. 2000;10:195–204
  15. Yee S. In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man – fact or myth. Pharm. Res. 1997;14:763–766

PII: S0944-7113(07)00047-5

doi: 10.1016/j.phymed.2007.03.008

Phytomedicine
Volume 15, Issue 5 , Pages 373-377 , 15 May 2008

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