Phytomedicine
Volume 16, Issue 2 , Pages 265-270 , March 2009

Neurobehavioral effect of essential oil of Cymbopogon citratus in mice

  • M.M. Blanco

      Affiliations

    • Current address: Department of Physiology, Federal University of São Paulo, Brazil.
    • Both authors contributed equally to the work.
    • ,
  • C.A.R.A. Costa

      Affiliations

    • Both authors contributed equally to the work.
    • ,
  • A.O. Freire

      Affiliations

    • Current address: Department of Physiology, Federal University of São Paulo, Brazil.
    • ,
  • J.G. Santos Jr.

      Affiliations

    • Current address: Department of Physiology, Federal University of São Paulo, Brazil.
    • ,
  • M. Costa

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +551438116253; fax: +551438153744.

References 

  1. Adams RP. Identification of Essential oil Components by Gas Chromatography/Mass Spectroscopy. Carol Stream: Allured Publ. Corporation; 1995;
  2. Bourin M, Hascoët M. The mouse light/dark box test. Eur. J. Pharmacol. 2003;463:55–65
  3. Carlini EA. Plants and the central nervous system. Pharmacol. Biochem. Behav. 2003;3:501–512
  4. Carlini EA, Contar JDP, Silva-Filho AR, da Silveira-Filho NG, Frochtengarten ML, Bueno OF. Pharmacology of lemongrass (Cymbopogon citratus Stapf). I. Effects of teas prepared from the leaves on laboratory animals. J. Ethnopharmacol. 1986;17(1):37–64
  5. Carvalho-Freitas MIR, Costa M. Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L. Biol. Pharm. Bull. 2002;25(12):1629–1633
  6. De-Oliveira ACAX, Ribeiro-Pinto LF, Otto SS, Gonçalves A, Paumgartten FJR. Induction of liver monooxygenases by beta-myrcene. Toxicology. 1997;124:135–140
  7. Di Stasi LC, Santos EMG, Hiruma CA. Plantas medicinais na Amazônia. São Paulo: UNESP; 1989;p. 194
  8. Duke JA. Handbook of Medical Herbs. seventh ed. Florida: CPR Press; 1989;(Reprint)
  9. File SE. Factors controlling measures of anxiety and responses to novelty in the mouse. Behav. Brain Res. 2001;125:151–157
  10. Fujimoto JM, Pearce KB, Plaa GL. Barbiturate metabolism as affected by certain agents acting on the liver. J. Pharmacol. Exp. Ther. 1960;129:139–143
  11. Hodgson E. Toxicity testing and risk assessment. In:  Hodgson E,  Levi PE editor. Textbook of Modern Toxicology. Connecticut: Applenton & Lange; 1997;p. 285–337
  12. Leite JR, Seabra MLV, Maluf E, Assolant K, Suchecki D, Tufik S, et al. Pharmacology of lemongrass (Cymbopogon citratus Stapf). III. Assessment of eventual toxic, hypnotic and anxiolytic effects on humans. J. Ethnopharmacol. 1986;17(1):75–83
  13. Lister RG. Ethologically-based animal models of anxiety disorders. Pharmacol. Pharmac. Ther. 1990;46:321–340
  14. Loscher W, Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. 1988;3:145–181
  15. McLafferty FW, Stauffer D. The Wiley/NBS Registry of Mass Spectral Data. vol. 1–2. New York: Wiley; 1989;
  16. Nakamura Y, Miyamoto M, Murakami A, Ohigashi H, Osawa T, Uchida K. A phase II detoxification enzyme inducer from lemongrass: identification of citral and involvement of electrophilic reaction in the enzyme induction. Biochem. Biophys. Res. Commun. 2003;302:593–600
  17. Phillipson JD. Phytochemistry and medicinal plants. Phytochemistry. 2001;56:237–243
  18. Pultrini AM, Galindo LA, Costa M. Effect of the essential oil from Citrus aurantium L. in experimental anxiety models in mice. Life Sci. 2006;78:1720–1725
  19. Seth G, Kokate CK, Varma KC. Effect of essential oil of Cymbopogon citratus Stapf. on central nervous system. Indian J. Exp. Biol. 1976;14:370–371
  20. Souza-Formigoni ML, Lodder HM, Gianotti-Filho O, Ferreira TM, Carlini EA. Pharmacology of lemongrass (Cymbopogon citratus Stapf) II. Effects of daily two months administration in male and female rats and in offspring exposed “in utero”. J. Ethnopharmacol. 1986;17(1):65–74
  21. Tortoriello J, Romero O. Plants used by Mexican traditional medicine with presumable sedative properties: an ethnobotanical approach. Arch. Med. Res. 1992;23:111–116
  22. Vale TG, Furtado EC, Santos JG, Viana GSB. Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) N.E. Brown. Phytomedicine. 2002;9:709–714
  23. Viana GSB, Vale TG, Pinho RSN, Matos FJA. Antinociceptive effect of the essential oil from Cymbopogon citratus in mice. J. Ethnopharmacol. 2000;70:323–327
  24. Viana GSB, Vale TG, Silva CMM, Matos FJA. Anticonvulsant activity of essential oils and active principles from chemotypes of Lippia alba (Mill.) N.E. Brown. Biol. Pharm. Bull. 2000;23(11):1314–1317
  25. White HS. Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia. 1997;38(Suppl. 1):S9–S17

PII: S0944-7113(07)00071-2

doi: 10.1016/j.phymed.2007.04.007

Phytomedicine
Volume 16, Issue 2 , Pages 265-270 , March 2009

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