Phytomedicine
Volume 16, Issue 2 , Pages 258-261, March 2009

Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity

  • A. Kato

      Affiliations

    • Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • Corresponding Author InformationCorresponding author. Fax: +81764345155.
    • ,
  • H. Yasuko

      Affiliations

    • Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
    • ,
  • H. Goto

      Affiliations

    • Department of Kampo Diagnostics, Institute of Natural Medicine, Toyama 930-0194, Japan
    • ,
  • J. Hollinshead

      Affiliations

    • Institute of Grassland and Environmental Research, Plas Gogerddan, Aberystwyth, Ceredigion SY23 3EB, UK
    • ,
  • R.J. Nash

      Affiliations

    • Institute of Grassland and Environmental Research, Plas Gogerddan, Aberystwyth, Ceredigion SY23 3EB, UK
    • ,
  • I. Adachi

      Affiliations

    • Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

Abstract 

Aldose reductase inhibitors have considerable potential for the treatment of diabetic complications, without increased risk of hypoglycemia. Search for components inhibiting aldose reductase led to the discovery of active compounds contained in Evodia rutaecarpa Bentham (Rutaceae), which is the one of the component of Kampo-herbal medicine. The hot water extract from the E. rutaecarpa was subjected to distribution or gel filtration chromatography to give an active compound, N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one (rhetsinine). It inhibited aldose reductase with IC50 values of 24.1μM. Furthermore, rhetsinine inhibited sorbitol accumulation by 79.3% at 100μM. These results suggested that the E. rutaecarpa derived component, rhetsinine, would be potentially useful in the treatment of diabetic complications.

Keywords: Evodia rutaecarpa, Aldose reductase, Rhetsinine, Diabetic complications

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PII: S0944-7113(07)00072-4

doi:10.1016/j.phymed.2007.04.008

Phytomedicine
Volume 16, Issue 2 , Pages 258-261, March 2009

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