Phytomedicine
Volume 16, Issue 1 , Pages 47-55 , January 2009

Whole body protection against lethal ionizing radiation in mice by REC-2001: A semi-purified fraction of Podophyllum hexandrum

  • M. Lata

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • Corresponding Author InformationCorresponding author. Tel.: +911123905153, 27564145; fax: +911123919509.
    • ,
  • J. Prasad

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • S. Singh

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • R. Kumar

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • L. Singh

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • P. Chaudhary

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • R. Arora

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • R. Chawla

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • S. Tyagi

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • N.L. Soni

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • R.K. Sagar

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • M. Devi

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • R.K. Sharma

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India
    • ,
  • S.C. Puri

      Affiliations

    • Natural Products Chemistry Division, Regional Research Laboratory (CSIR), Canal Road, Jammu 180001, India
    • ,
  • R.P. Tripathi

      Affiliations

    • Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Timarpur, Delhi 110 054, India

References 

  1. Abalea V, Cillard J, Dubos MP, Sergent O, Cillard P, Morel I. Repair of iron induced DNA oxidation by the flavonoid myricetin in primary rat hepatocyte culture. Free Radic. Biol. Med. 1999;26:1457–1466
  2. Arora R, Gupta D, Chawla R, Sagar R, Sharma AK, Prasad J, et al. Radioprotection by plant products: present status and future prospects. Phytother. Res. 2005;19:1–22
  3. Beutner KR. Podophyllotoxin in the treatment of genital warts. Curr. Probl. Dermatol. 1996;24:227–232
  4. Blasko G, Cordell GA. Recent developments in chemistry of plant derived anticancer agents. In:  Wagner H,  Hiroshi H,  Farnsworth NR editor. Economic and Medicinal Plant Research. New York: Academic Press; 1998;
  5. Bump EA, Malaker K. Radio Protectors: Chemical, Biological and Clinical Perspectives. Boca Raton, FL: CRC Press; 1998;p. 431
  6. Chang LW, Yang CM, Chen CF, Deng JF. Experimental podophyllotoxin (bajiaolian) poisoning: 1. Effect: on the nervous system. Biomed. Environ. Sci. 1992;5(4):283–292
  7. Chawla R, Arora R, Kumar R, Sharma AK, Prasad J, Singh S, et al. Antioxidant activity of fractionated extracts of high altitude Podophyllum hexandrum in radiation protection. Mol. Cell. Biochem. 2005;273:193–208
  8. Duh PD, Yen GC. Antioxidative activity of three herbal water extracts. Food Chem. 1997;42:629–645
  9. Giambarresi L, Jacobs AJ. Radioprotectants. In:  Conklin JJ,  Walker I editor. Military Radiobiology. London: Academic Press Inc; 1987;p. 265–301
  10. Goel HC, Prasad J, Singh S, Sagar R, Kumar IP, Sinha AK. Radioprotection by herbal preparation of Hippophae rhamnoides, RH-3, against whole body lethal irradiation in mice. Phytomedicine. 2002;9:15–25
  11. Goel HC, Agrawala PK, Pathania V, Malhotra N. Immunomodulatory and cytoprotective role of RP-1 in γ-irradiated mice. Mol. Cell. Biochem. 2003;254:73–81
  12. Gowdey G, Lee RK, Carpenter WM. Treatment of HIV-related hairy leukoplakia with podophyllum resins 25% solution. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endocrinol. 1995;79:64–67
  13. Jagetia GC, Aruna R. The herbal preparation of Abana protects against radiation-induced micronuclei in the mouse bone marrow. Mutat. Res. 1997;393:157–163
  14. Kitts DD, Wijewickreme AN, Hu C. Antioxidant properties of a North American ginseng extract. Mol. Cell. Biochem. 2000;203:1–10
  15. Kumar IP, Goel HC. Iron chelation and related properties of Podophyllum hexandrum, a possible role in radioprotection. Indian J. Exp. Biol. 2000;38:1003–1006
  16. Maisin JR. Chemical radioprotection – past, present and future prospects. Int. J. Radiat. Biol. 1998;73:443–450
  17. Miller LC, Tainter ML. Estimation of the ED50 and its error by means of logarithmic-probate graph paper. Proc. Soc. Exp. Biol. Med. 1944;57:261
  18. Mittal A, Pathania V, Agarwala PK, Prasad J, Singh S, Goel HC. Influence of Podophyllum hexandrum on endogenous antioxidant defense system in mice: possible role in radioprotection. J. Ethanopharmacol. 2001;76:253–262
  19. Sagar RK, Chawla R, Arora R, Singh S, Krishna B, Sharma RK, et al. Protection of the hemopoietic system by Podophyllum hexandrum against gamma radiation-induced damage. Planta Med. 2006;72:114–120
  20. Sestili P, Gudarelli A, Marina D, Cantoni O. Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert butyl hydro peroxide: free radical scavenging versus iron chelating mechanism. Free Radic. Biol. Med. 1998;25:196–200
  21. Shimoi K, Masuda S, Furogori M, Esaki S, Kinae N. Radioprotective effect of antioxidative flavonoids in gamma ray irradiated mice. Carcinogenesis. 1994;15:2669–2672
  22. Singh J, Shah NC. Podophyllum: a review. Curr. Res. Med. Arom. Plants. 1994;116:53–83
  23. Sweeney TR. A Survey of Compounds from the Antiradiation Drug Development Program of the US Army Medical Research and Development Command. Washington, DC, USA: Government Printing Office; 1979;pp. 308–318
  24. Uma Devi P, Ganasoundari A, Rao BSS, Srinivasan KK. In vivo radioprotection by Ocimum sanctum flavonoids: survival of mice. Radiat. Res. 1999;151:74–78
  25. Weiss JF, Landauer MR. Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology. 2003;189:1–20
  26. Wong SK, Tsui SK, Kwan SY, Su XL, Lin RC. Identification and characterization of Podophyllum emodi by API-LC/MS/MS. J. Mass Spectrom. 2000;35:1246–1251

PII: S0944-7113(07)00074-8

doi: 10.1016/j.phymed.2007.04.010

Phytomedicine
Volume 16, Issue 1 , Pages 47-55 , January 2009

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