Phytomedicine
Volume 16, Issue 2 , Pages 222-226, March 2009

Acute toxicity of Orthosiphon stamineus Benth standardized extract in Sprague Dawley rats

  • Noor Rain Abdullah

      Affiliations

    • Herbal Medicine Research Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia
    • Corresponding Author InformationCorresponding author. Tel.: +60326162632/2633; fax: +60326934114.
    • ,
  • Zakiah Ismail

      Affiliations

    • Herbal Medicine Research Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia
    • ,
  • Zhari Ismail

      Affiliations

    • School of Pharmaceutical Sciences, University Sains Malaysia, 11800 Pulau Pinang, Malaysia

Abstract 

The acute toxicity of standardized extract of Orthosiphon stamineus was studied in Sprague Dawley rats. The rats were administered a single dose of 5000mg/kg body weight (BW) orally on Day 0 and observed for 14 days. There were no deaths recorded and the animals did not show signs of toxicity during the experimental period. The effect of the extract on general behavior, BW, food and water intake, relative organ weight per 100g BW, hematology and clinical biochemistry were measured. All the parameters measured were unaffected as compared to the control. The acute toxicity LD50 was estimated to be >5000mg/kg BW.

Keywords: Orthosiphon stamineus, Safety profile, Acute toxicity

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PII: S0944-7113(07)00077-3

doi:10.1016/j.phymed.2007.04.013

Phytomedicine
Volume 16, Issue 2 , Pages 222-226, March 2009

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