Phytomedicine
Volume 16, Issue 2 , Pages 222-226 , March 2009

Acute toxicity of Orthosiphon stamineus Benth standardized extract in Sprague Dawley rats

  • Noor Rain Abdullah

      Affiliations

    • Herbal Medicine Research Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia
    • Corresponding Author InformationCorresponding author. Tel.: +60326162632/2633; fax: +60326934114.
    • ,
  • Zakiah Ismail

      Affiliations

    • Herbal Medicine Research Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia
    • ,
  • Zhari Ismail

      Affiliations

    • School of Pharmaceutical Sciences, University Sains Malaysia, 11800 Pulau Pinang, Malaysia

References 

  1. Akowuah AG, Zhari I, Norhayati I, Sadikun A, Khamsah SM. Sinensitin, eupatorin, 3′-hydroxy-5,6,7,4′-tetramethoxyflavone and rosmarinic acid contents and antioxidative effect of Orthosiphon stamineus from Malaysia. Food Chem. 2004;87:569–666
  2. Awale S, Tezuka Y, Banskota AH, Adnyana IK, Kadota S. Highly-oxygenated isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia and their nitric oxide inhibitory activity. Chem. Pharmacol. Bull. 2003;51(3):268–275
  3. Hollman PC, Katan MB. Dietary flavonoids: intake, health effects and bioavailability. Food Chem. Toxicol. 1999;37:937–942
  4. Hong Loon Y, Woe Wong J, Ping Yap S, Haay Yuen K. Determination of flavonoids from Orthosiphon stamineus in plasma using a simple HPLC method with ultraviolet detection. J. Chromatogr. B. 2005;816:161–166
  5. Ministry of Health Malaysia. Principles and Guide to Ethical Use of Laboratory Animals. Ed. Institute for Medical Research; 2000;pp. 1–54
  6. Olah NK, Radu L, Mogosan C, Hanganu D, Gocan S. Phytochemical and pharmacological studies on Orthosiphon stamineus Benth. (Lamiaceae) hydroalcoholic extract. J. Pharma. Biochem. Anal. 2003;33:117–123
  7. Organization for Economic Cooperation and Development (OECD), 1981. Guidelines for Testing of Chemicals. Section 4-Health Effect, Part 425, Acute Oral Toxicity.
  8. PT Eisai Indonesia, (Ed.), 1995. Medicinal Herb Index in Indonesia, second ed., PT Eisai Indonesia, Indonesia.
  9. Ringler, D.H., Dabich, L., 1979. Haematology and clinical biochemistry. In: The Laboratory Rat, vol. 1, Academic Press, London.
  10. Schut GA, Zwaving JH. Pharmacological investagation of some lipophilic flavonoids from Orthosiphon aristatus. Fitoterapia. 1993;64:99–102
  11. Taconic Technical Library, Hematological Clinical Biochemistry values Sprague Dawley rats. 〈http://www.taconic.com/healthr/hematology/sdheme.htm〉.
  12. Tezuka Y, Stampoulis P, Banskota AH, Awale S, Tran KQ, Saiki I. Constituents of the Vietnamese medicinal plant Orthosiphon stamineus. Chem. Pharma. Bull. 2000;48:1711–1719
  13. Waynforth, H.B., 1980. Experimental and Surgical Technique in the Rat. London, UK.
  14. Witthawaskul P, Panthong A, Kanjanapothi D, Taesothikul T, Lertprasertsuke N. Acute and sub acute toxicities of the saponin mixture isolated from Schefflera leucantha Viguier. J. Ethnopharmacol. 2003;89:115–121
  15. World Health Organization (WHO), 1998. Basic OECD principles of Good Laboratory Practice (GLP) 〈www.who.int/tdr/publication〉.

PII: S0944-7113(07)00077-3

doi: 10.1016/j.phymed.2007.04.013

Phytomedicine
Volume 16, Issue 2 , Pages 222-226 , March 2009

Article Tools