Phytomedicine
Volume 15, Issue 5 , Pages 386-388, 15 May 2008

Three angiotensin-converting enzyme inhibitors from Rabdosia coetsa

  • Q.-L. Li

      Affiliations

    • Chengdu Institute of Biology, Chinese Academy of Sciences, P.O. Box 416, Chengdu 610041, PR China
    • ,
  • B.-G. Li

      Affiliations

    • Chengdu Institute of Biology, Chinese Academy of Sciences, P.O. Box 416, Chengdu 610041, PR China
    • ,
  • Y. Zhang

      Affiliations

    • Pharmaceutical Institute of Di-Ao Pharmaceutical Group, Chengdu 610041, PR China
    • ,
  • X.-P. Gao

      Affiliations

    • Pharmaceutical Institute of Di-Ao Pharmaceutical Group, Chengdu 610041, PR China
    • ,
  • C.-Q. Li

      Affiliations

    • Chengdu Institute of Biology, Chinese Academy of Sciences, P.O. Box 416, Chengdu 610041, PR China
    • ,
  • G.-L. Zhang

      Affiliations

    • Chengdu Institute of Biology, Chinese Academy of Sciences, P.O. Box 416, Chengdu 610041, PR China
    • Corresponding Author InformationCorresponding author. Tel./fax: +862885225401.

Abstract 

The EtOAc extract of Rabdosia coetsa showed angiotensin-converting enzyme (ACE) inhibitory activity. Bioassay-guided isolation of this extract yielded ethyl caffeate (1), rosmarinic acid (2) and methyl rosmarinate (3), which inhibited ACE activity by 32.42%, 55.19% and 39.50% respectively, at the concentration of 10μg/ml.

Keywords: Rabdosia coetsa, Rosmarinic acid, Angiotensin-converting enzyme inhibitor

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PII: S0944-7113(07)00234-6

doi:10.1016/j.phymed.2007.09.013

Phytomedicine
Volume 15, Issue 5 , Pages 386-388, 15 May 2008

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