Phytomedicine
Volume 15, Issue 1 , Pages 23-30, 25 January 2008

Enhanced antioxidant bioactivity of Salvia miltiorrhiza (Danshen) products prepared using nanotechnology

  • Je-Ruei Liu

      Affiliations

    • Department of Animal Science and Technology and Institute of Biotechnology, National Taiwan University, Taipei 102, Taiwan, ROC
    • ,
  • Guo-Feng Chen

      Affiliations

    • Department of Biotechnology, National Formosa University, 64 Wunhua Road, Huwei Town, Yunlin 632, Taiwan, ROC
    • ,
  • Hui-Nung Shih

      Affiliations

    • Department of Biotechnology, National Formosa University, 64 Wunhua Road, Huwei Town, Yunlin 632, Taiwan, ROC
    • ,
  • Ping-Chung Kuo

      Affiliations

    • Department of Biotechnology, National Formosa University, 64 Wunhua Road, Huwei Town, Yunlin 632, Taiwan, ROC
    • Corresponding Author InformationCorresponding author. Tel.: +88656315491; fax: +88656315502.

Abstract 

The traditional Chinese medicine, Salvia miltiorrhiza (Danshen), promotes blood circulation and relieves blood stasis, also demonstrating good antioxidant activity. In the present study, therefore, the antioxidant activities of medicinal plant materials prepared using nanotechnology or traditional grinding methods were compared using three biological assays. It was found that the nanotechnology preparation had stronger antioxidant bioactivities. Complementary quantitative analysis of four active constituents, salvianolic acid B, cryptotanshinone, tanshinone I and tanshinone IIA, by HPLC revealed only marked differences for salvianolic acid B. The results indicate that the polar active constituent in the nanotechnology samples was released faster compared to the traditionally powdered samples.

Keywords: Traditional Chinese medicine, Antioxidant activity, HPLC, Salvianolic acid B

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PII: S0944-7113(07)00285-1

doi:10.1016/j.phymed.2007.11.012

Phytomedicine
Volume 15, Issue 1 , Pages 23-30, 25 January 2008

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