Phytomedicine
Volume 15, Issue 5 , Pages 367-372 , 15 May 2008

In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon

  • Maria Fâni Dolabela

      Affiliations

    • Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil
  • ,
  • Salma G. Oliveira

      Affiliations

    • Laboratório de Malária, Instituto Evandro Chagas, BR 316, Km 7, Ananindeua, CEP 67030-070, PA, Brazil
  • ,
  • José Maria Nascimento

      Affiliations

    • Laboratório de Malária, Instituto Evandro Chagas, BR 316, Km 7, Ananindeua, CEP 67030-070, PA, Brazil
  • ,
  • José Maria Peres

      Affiliations

    • Laboratório de Malária, Instituto Evandro Chagas, BR 316, Km 7, Ananindeua, CEP 67030-070, PA, Brazil
  • ,
  • Hildebert Wagner

      Affiliations

    • Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München, Department Pharmazie, Zentrum für Pharmaforschung, Butenandtstraße 5, D-81377 München-Grosshadern, Germany
  • ,
  • Marinete Marins Póvoa

      Affiliations

    • Laboratório de Malária, Instituto Evandro Chagas, BR 316, Km 7, Ananindeua, CEP 67030-070, PA, Brazil
  • ,
  • Alaíde Braga de Oliveira

      Affiliations

    • Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +553134096972; fax: +553134096935.

References 

  1. Basco L, Mitaku S, Skaltsounis A-L, Ravelomanantsoa N, Tillequin F, Koch M, et al. In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum. Antimicrob. Agents Chemother. 1994;38:1169–1171
  2. Baumert A, Kuzovkina IN, Krauss , Hieke GM, Gröger D. Biosynthesis of rutacridone in tissue cultures of Ruta graveolens L. Plant Cell Rep. 1982;1:168–171
  3. Bevalot F, Fournet A, Moretti C, Vaquette J. Alkaloids from Esenbeckia pilocarpoides. Planta Med. 1984;50:522–523
  4. Brandão MGL, Grande TSM, Rocha FMM, Sawyer DR, Krettli AU. Survey of medicinal plants used as antimalarials in the Amazon. J. Ethnopharmacol. 1992;36:175–182
  5. Carvalho LH, Brandão MGL, Santos-Filho D, Lopes JLC, Krettli AU. Antimalarial activity of crude extracts from Brazilian plants studied in vivo in Plasmodium berghei-infected mice and in vitro against Palsmodium falciparum in culture. Braz. J. Med. Biol. Res. 1991;24:1113–1123
  6. Dreyer DL. Alkaloids, limonoids and furocoumarins from three Mexican Esenbeckia species. Phytochemistry. 1980;19:941–944
  7. Dreyer DL, Pickering MV, Cohan P. Distribution of limonoids in the Rutaceae. Phytochemistry. 1972;11:705–713
  8. Fidock DA, Rosenthal PJ, Croft SL, Brun R, Niwaka S. Antimalarial drug discovery: efficacy models for compounds screening. Nat. Rev. Drug Discov. 2004;3:509–520
  9. Fujioka H, Nishiyama Y, Furukawa H, Kumada N. In vitro and in vivo activities of atalaphilline and related acridone alkaloids against rodent malaria. Antimicrob. Agents Chemother. 1989;33:6–9
  10. Fujioka H, Kato N, Fujita M, Fujimura K, Nishiyama Y. Activities of new acridone alkaloid derivatives against Plasmodium yoelii in vitro. Arzneim.-Forsch./Drug Res. 1990;40:1026–1029
  11. Kuzovkina I, Al’terman I, Schneider B. Specific accumulation and revised structures of acridone alkaloid glucosides in the tips of transformed roots of Ruta graveolens. Phytochemistry. 2004;65:1095–1100
  12. MS/SVS – Ministério da Saúde/Secretaria de Vigilância Sanitária, 2007. Situação epidemiológica da malária no Brasil: Brasília, Brasil.
  13. Muriithi MW, Abraham WR, Addae-Kyereme J, Scowen I, Croft SL, Gitu PM, et al. Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normeliopicine. J. Nat. Prod. 2002;65:956–959
  14. Napolitano HB, Silva M, Ellena J, Rodrigues BDG, Almeida ALC, Vieira PC, et al. Aurapten, a coumarin with growth inhibition against Leishmania major promastigotes. Braz. J. Med. Biol. Res. 2004;37:1847–1852
  15. Oliveira FM, Santana AEG, Conserva LM, Maia JG, Guilhon GMP. Alkaloids and coumarins from Esenbeckia species. Phytochemistry. 1996;41:647–649
  16. Randrianarivelojosia M, Rasidimanana VT, Rabarison H, Cheplogoi PK, Ratsimbason M, Mulholland D, et al. Plants traditionally prescribed to treat tazo (malaria) in the eastern region of Madagascar. Malaria J. 2003;2:25;〈http://www.malariajournal.com/content/2/1/25〉
  17. Ridley RG. Medical need, scientific opportunity and the drive for antimalarial drugs. Nature. 2002;415:686–693
  18. Rieckman, K.H., 1980. Susceptibility of cultured parasites of Plasmodium falciparum to antimalarial drugs. In: World Health Organization (Ed.), Tropical Diseases Research Series III. The In Vitro Cultivation of Pathogens of Tropical Diseases. Schwabe & Co. AG., Geneva, pp. 35–50.
  19. Rios MY, Aguilar-Guadarrama AB, Delgado G. Furoquinoline alkaloids, furocoumarins and terpenes from Esenbeckia litoralis. Biochem. Syst. Ecol. 2002;30:977–979
  20. Rosenthal PJ. Antimalarial drug discovery: old and new approaches. J. Exp. Biol. 2003;206:3735–3744
  21. Spatafora C, Tringali C. Bioactive metabolites from the bark of Fagara macrophylla. Phytochem. Anal. 1997;8:139–142
  22. Trager W, Jensen JB. Human malaria parasites in continuous culture. Science. 1976;193:673–675
  23. Trani M, Carbonetti A, Delle Monache G, Delle Monache F. Dhydrochalcones and coumarins of Esenbeckia grandiflora subsp. brevipetiolata. Fitoterapia. 2004;75:99–102
  24. Waterman PG. The chemical systematics of alkaloids: a review emphasising the contribution of Robert Hegnauer. Biochem. Syst. Ecol. 1999;27:395–406
  25. WHO – World Health Organization, 2005. World Malaria Report 〈http://www.who.int/malaria〉.
  26. Willcox ML, Bodeker G. Traditional herbal medicines for malaria. Br. Med. J. 2004;329:1156–1159
  27. Wright CW. Plant derived antimalarial agents: new leads and challenges. Phytochem. Rev. 2005;4:55–61

PII: S0944-7113(08)00008-1

doi: 10.1016/j.phymed.2008.02.001

Phytomedicine
Volume 15, Issue 5 , Pages 367-372 , 15 May 2008