Phytomedicine
Volume 15, Issue 12 , Pages 1125-1129 , December 2008

Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata

  • Anastasia Karioti

      Affiliations

    • Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, 157 71 Athens, Greece
    • ,
  • Helen Skaltsa

      Affiliations

    • Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, 157 71 Athens, Greece
    • ,
  • Xujie Zhang

      Affiliations

    • Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, NY 11794-3400, USA
    • ,
  • Peter J. Tonge

      Affiliations

    • Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, NY 11794-3400, USA
    • ,
  • Remo Perozzo

      Affiliations

    • School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva 4, Switzerland
    • ,
  • Marcel Kaiser

      Affiliations

    • Department of Medical Parasitology, Swiss Tropical Institute, 4002 Basel, Switzerland
    • ,
  • Scott G. Franzblau

      Affiliations

    • Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    • ,
  • Deniz Tasdemir

      Affiliations

    • Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London WC1N 1AX, UK
    • Corresponding Author InformationCorresponding author. Tel.: +442077535845; fax: +442077535909.

References 

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  10. Karioti A, Skaltsa H, Linden A, Perozzo R, Brun R, Tasdemir D. Anthecularin, a novel sesquiterpene lactone from Anthemis auriculata with antiprotozoal activity. J. Org. Chem. 2007;72:8103–8106
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  19. Tasdemir D, Lack G, Brun R, Rüedi P, Scapozza L, Perozzo R. Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J. Med. Chem. 2006;49:3345–3353
  20. Tasdemir D, Topaloglu B, Perozzo R, Brun R, O’Neill R, Carballeira NM, et al. Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli. Bioorg. Med. Chem. 2007;15:6834–6845
  21. Theodori R, Karioti A, Rancic A, Skaltsa H. Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity. J. Nat. Prod. 2006;69:662–664
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PII: S0944-7113(08)00040-8

doi: 10.1016/j.phymed.2008.02.018

Phytomedicine
Volume 15, Issue 12 , Pages 1125-1129 , December 2008

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