Phytomedicine
Volume 15, Issue 11 , Pages 1016-1020, November 2008

Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight

  • Yun-ru Peng

      Affiliations

    • Center of Drug Metabolism and Pharmacokinetic, China Pharmaceutical University, Nanjing 210009, China
    • Jiangsu Provincial Institute of Traditional Chinese Medicine, Nanjing 210028, China
    • ,
  • You-bin Li

      Affiliations

    • Jiangsu Provincial Institute of Traditional Chinese Medicine, Nanjing 210028, China
    • ,
  • Xiao-dong Liu

      Affiliations

    • Center of Drug Metabolism and Pharmacokinetic, China Pharmaceutical University, Nanjing 210009, China
    • Corresponding Author InformationCorresponding author. Tel.: +862585637847; fax: +862585639640.
    • ,
  • Jian-feng Zhang

      Affiliations

    • Jiangsu Provincial Institute of Traditional Chinese Medicine, Nanjing 210028, China
    • ,
  • Jin-ao Duan

      Affiliations

    • Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China

Abstract 

The antitumor activities of six C-21 steroidal glycosides isolated from the root tuber of Cynanchum auriculatum Royle ex Wight were performed according to a microculture tetrazolium (MTT) method on human tumor cell lines SMMC-7721, MCF-7 and Hela. Of these compounds, caudatin-2,6-dideoxy-3-O-methy-β-d-cymaropyranoside and caudatin were found to be of the highest effects against human tumor cell line SMMC–7721 with IC50 values of 13.49 and 24.95μM, respectively. Then the in vivo assay further showed that caudatin-2,6-dideoxy-3-O-methy-β-d-cymaropyranoside and caudatin significantly inhibited the growth of transplantable H22 tumors in mice.

Keywords: Cynanchum auriculatum Royle ex Wight, C-21 steroidal glycosides, Caudatin-2, 6-dideoxy-3-O-methy-β-d-cymaropyranoside, Caudatin, Human tumor cell lines, Antitumor activity

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PII: S0944-7113(08)00043-3

doi:10.1016/j.phymed.2008.02.021

Phytomedicine
Volume 15, Issue 11 , Pages 1016-1020, November 2008

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