Phytomedicine
Volume 15, Issue 11 , Pages 1016-1020 , November 2008

Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight

  • Yun-ru Peng

      Affiliations

    • Center of Drug Metabolism and Pharmacokinetic, China Pharmaceutical University, Nanjing 210009, China
    • Jiangsu Provincial Institute of Traditional Chinese Medicine, Nanjing 210028, China
    • ,
  • You-bin Li

      Affiliations

    • Jiangsu Provincial Institute of Traditional Chinese Medicine, Nanjing 210028, China
    • ,
  • Xiao-dong Liu

      Affiliations

    • Center of Drug Metabolism and Pharmacokinetic, China Pharmaceutical University, Nanjing 210009, China
    • Corresponding Author InformationCorresponding author. Tel.: +862585637847; fax: +862585639640.
    • ,
  • Jian-feng Zhang

      Affiliations

    • Jiangsu Provincial Institute of Traditional Chinese Medicine, Nanjing 210028, China
    • ,
  • Jin-ao Duan

      Affiliations

    • Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China

References 

  1. Chen JJ, Zhang ZX, Zhou J. Cynauricuosides A, B and C steroid glycosides from the root of Cynanchum auriculatum. Acta Bot. Yunnanica. 1990;12:197–210
  2. Shan L, Zhang WD, Zhang C, Liu RH, Su J, Zhou Y. Antitumor activity of crude extract and fractions from root tuber of Cynanchum auriculatum Royle ex Wight. Phytother. Res. 2005;19:259–261
  3. Simon G. Pharmaceutical pregnane derivatives. Br. UK Patent Appl. 1996;26:GB2296496 A 19960703
  4. Wang DY, Zhang HQ, Li X. Apoptosis induced by the C21 sterols in Baishouwu and its mechanism of action in hepatoma. Acta Pharm. Sin. 2007;42:366–370
  5. Zhang JF, Li YB, Li CL, Jiang JQ. Chemical constituents in root tuber of Cynanchum auriculatum. China J. Chin. Mater. Med. 2006;31:814–816
  6. Zhang RS, Ye YP, Liu XL. Studies on in vitro antitumor activity of total steroidal glycoside from the root of Cynanchum auriculatum. Chin. Trad. Herbal Drugs. 2000;31:599–601
  7. Zhang RS, Ye YP, Shen YM, Liang HL. Two new cytotoxic C-21 steroidal glycosides from the root of Cynanchum auriculatum. Tetrahedron. 2000;56:3875–3879
  8. Zhang RS, Liu YL, Wang YQ, Ye YP, Li XY. Cytotoxic and apoptosis-inducing properties of auriculoside A in tumor cells. Chem. Biodiversity. 2007;4:887–892

PII: S0944-7113(08)00043-3

doi: 10.1016/j.phymed.2008.02.021

Phytomedicine
Volume 15, Issue 11 , Pages 1016-1020 , November 2008

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