Phytomedicine
Volume 15, Issue 12 , Pages 1130-1134, December 2008

Antimalarial, antimycobacterial and cytotoxic limonoids from Chisocheton siamensis

  • W. Maneerat

      Affiliations

    • School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand
    • ,
  • S. Laphookhieo

      Affiliations

    • School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand
    • Corresponding Author InformationCorresponding author. Tel.: +6653916224; fax: +6653916776.
    • ,
  • S. Koysomboon

      Affiliations

    • Faculty of Arts and Sciences, Prince of Songkla University, Muang, Suratthani 84100, Thailand
    • ,
  • K. Chantrapromma

      Affiliations

    • Institute of Research and Development, Walailak University, Thaiburi, Thasala, Nakhon Si Thammarat 80160, Thailand

Abstract 

Five limonoids isolated from the seeds of Chisocheton siamensis were tested for their antimalarial activity against Plasmodium falciparum, antimycobacterial activity against Mycobacterium tuberculosis and cytotoxic activity against NCI-H187 (human small cell lung cancer), KB (oral human epidermal carcinoma) and MCF-7 (breast cancer) cancer cell lines. All limonoids (1–5) showed inhibitory effect against Plasmodium falciparum with IC50 values ranging from 2.06 to 6.31μg/ml. Only azadiradione (2) exhibited strong inhibitory effect against Mycobacterium tuberculosis with the MIC of 6.25μg/ml. Compounds 1–4 also showed cytotoxic activity against NCI-H187, KB and MCF-7 cancer cell lines and dysobinine (1) had the highest activity with IC50 of 1.67, 3.17 and 2.15μg/ml, respectively.

Keywords: Chisocheton siamensis, Meliaceae, Limonoids, Antimalarial activity, Antimycobacterial activity, Cytotoxic activity

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PII: S0944-7113(08)00102-5

doi:10.1016/j.phymed.2008.05.004

Phytomedicine
Volume 15, Issue 12 , Pages 1130-1134, December 2008

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