Phytomedicine
Volume 15, Issue 12 , Pages 1087-1092 , December 2008

Endothelium-dependent induction of vasorelaxation by Melissa officinalis L. ssp. officinalis in rat isolated thoracic aorta

  • S. Ersoy

      Affiliations

    • Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
    • ,
  • I. Orhan

      Affiliations

    • Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +903122023186; fax: +903122235018.
    • ,
  • N.N. Turan

      Affiliations

    • Department of Pharmacology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
    • ,
  • G. Şahan

      Affiliations

    • Department of Pharmacology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
    • ,
  • M. Ark

      Affiliations

    • Department of Pharmacology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
    • ,
  • F. Tosun

      Affiliations

    • Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey

References 

  1. Almela L, Sanchez-Munoz B, Fernandez-Lopez JA, Roca MJ, Rabe V. Liquid chromatographic–mass spectrometric analysis of phenolics and free radical scavenging activity of rosemary extract from different raw material. J. Chromatogr. A. 2006;1120:221–229
  2. Anselm E, Chataigneau M, Ndiaye M, Chataigneau T, Schini-Kerth VB. Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src-and akt-dependent activation of eNOS. Cardiovasc. Res. 2007;73:404–413
  3. Babulka P. La mélisse (Melissa officinalis L.). Phytothérapie. 2005;3:114–117
  4. Basta A, Tzakou O, Couladis M. Composition of the leaves essential oil of Melissa officinalis s.1. from Greece. Flav. Fragr. J. 2005;20:642–644
  5. Baytop, T., 1999. Therapy with medicinal plants (past and present). Nobel Tip Kitabevleri, second ed., Istanbul.
  6. Brixius K, Willms S, Napp A, Tossios P, Ladage D, Bloch W, et al. Crataegus special extract WS1442 induces an endothelium-dependent, NO-mediated vasorelaxation via eNOS-phosphorylation at serine 1177. Cardiovasc. Drugs Ther. 2006;20:177–184
  7. Bolkent S, Yanardag R, Karabulut-Bulan O, Yesilyaprak B. Protective role of Melissa officinalis L. extract on liver of hyperlipidemic rats: A morphological and biochemical study. J. Ethnopharmacol. 2005;99:391–398
  8. Boyadzhiev L, Dimitrova V. Extraction and liquid membrane preconcentration of rosmarinic acid from lemon balm (Melissa officinalis L.). Sep. Sci. Technol. 2006;41:877–886
  9. Caniova A, Brandsteterova E. HPLC analysis of phenolic acids in Melissa officinalis. J. Liquid Chromatogr. Relat. Technol. 2001;24:2647–2659
  10. Enjalbert F, Bessiere JM, Pellecuer J, Privat G, Doucet G. Analyse des essences de Melisse. Fitoterapia. 1983;54:59–65
  11. Ganz P, Ganz W. Coronary blood flow and myocardial ischemia. In:  Braunwald E,  Zipes E,  Libby P editor. Heart Disease. A Textbook of Cardiovascular Medicine. sixth ed. London: W.B. Saunders Company; 2001;p. 1091–1113
  12. Gazola R, Machado D, Ruggiero C, Singi G, Alexandre MM. Lippia alba, Melissa officinalis and Cymbopogon citratus: effects of the aqueous extracts on the isolated hearts of rats. Pharmacol. Res. 2004;50:477–480
  13. Goto H, Shimada Y, Akechi Y, Kohta K, Hattori M, Terasawa K. Endothelium-dependent vasodilator effect of extract prepared from the roots of Paeonia lactiflora on isolated rat aorta. Planta Med. 1996;62:436–439
  14. Heitz A, Carnat A, Fraisse D, Carnat AP, Lamaison JL. Luteolin 3′-glucuronide, the major flavonoid from Melissa officinalis subsp. officinalis. Fitoterapia. 2000;71:201–202
  15. Herodez SS, Hadolin M, Skerget M, Knez Z. Solvent extraction study of antioxidants from balm (Melissa officinalis L.) leaves. Food Chem. 2003;80:275–282
  16. Kan Y, Gökbulut A, Kartal M, Konuklugil B, Yilmaz G. Development and validation of a liquid chromatographic method for the analysis of phenolic acids in Turkish Salvia species. Chromatographia. 2007;66:S147–S157
  17. Ko FN, Huang TF, Teng CM. Vasodilatory action mechanisms of apigenin isolated from Apium graveolens in rat thoracic aorta. Biochim. Biophys. Acta. 1991;1115:69–74
  18. Lee JW, Roh TC, Rho MC, Kim YK, Lee HS. Mechanisms of relaxant action of a pyranocoumarin from Peucedanum japonicum in isolated rat thoracic aorta. Planta Med. 2002;68:891–895
  19. Legssyer A, Ziyyat A, Mekh H, Bnouham M, Herrenknecht C, Roumy V, et al. Tannins and catechin gallate mediate the vasorelaxant effect of Arbutus unedo on the rat isolated aorta. Phytother. Res. 2004;18:889–894
  20. Mimica-Dukic N, Bozin B, Sokovic M, Simin N. Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil. J. Agric. Food Chem. 2004;52:2485–2489
  21. Mulkens A, Kapetanidis I. Flavonoides des feuilles de Melissa officinalis L. (Lamiaceae). Pharm. Acta Helv. 1987;62:19–22
  22. Rocha AP, Carvalho LC, Sousa MA, Madeira SV, Sousa PJ, Tano T, et al. Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (Açai) extracts in mesenteric vascular bed of the rat. Vascular Pharmacol. 2007;46:97–104
  23. Sadraei H, Ghannadi A, Malekshahi K. Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions. Fitoterapia. 2003;74:445–452
  24. Shimokawa H, Yasutake H, Fuji K, Owada MK, Nakaike R, Fukumoto Y, et al. The importance of the hyperpolarizing mechanism increases as the vessel size decreases in the endothelium-dependent relaxations in rat mesenteric circulation. J. Cardiovasc. Pharmacol. 1996;28:703–711
  25. Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolibdic-phosphotungtic acid reagents. Am. J. Enol. Viticult. 1965;16:144–158
  26. Stoclet JC, Chataigneau T, Ndiaye M, Oak MH, El Bedoui J, Chataigneau M, et al. Vascular protection by dietary polyphenols. Eur. J. Pharmacol. 2004;500:299–313
  27. Toth J, Mrlianova M, Tekelova D, Korenova M. Rosmarinic acid-An important phenolic active compound of lemon balm (Melissa officinalis L.). Acta Fac. Pharm. Univ. Comenianae. 2003;50:139–146
  28. Wichtl, M., 1994. Herbal Drugs and Phytopharmaceuticals, (Edited and translated from the second German edition by Grainger Bisset N.), Medpharm Scientific Publishers, Stuttgart.
  29. Yoshikawa M, Matsuda H, Morikawa T, Xie H, Nakamura S, Muraoka O. Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa. Bioorg. Med. Chem. 2006;14:7468–7475
  30. Ziakova A, Brandsteterova E, Blahova E. Matrix solid-phase dispersion for the liquid chromatographic determination of phenolic acids in Melissa officinalis. J. Chromatogr. A. 2003;983:271–275

PII: S0944-7113(08)00105-0

doi: 10.1016/j.phymed.2008.05.007

Phytomedicine
Volume 15, Issue 12 , Pages 1087-1092 , December 2008

Article Tools

* Image Usage & Resolution