Phytomedicine
Volume 15, Issue 12 , Pages 1108-1116 , December 2008

Efficacy of an aqueous Pelargonium sidoides extract against herpesvirus

  • P. Schnitzler

      Affiliations

    • Department of Virology, Hygiene Institute, University of Heidelberg, 69120 Heidelberg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +496221565016; fax: +496221565003.
    • ,
  • S. Schneider

      Affiliations

    • Department of Virology, Hygiene Institute, University of Heidelberg, 69120 Heidelberg, Germany
    • ,
  • F.C. Stintzing

      Affiliations

    • Institute of Food Sciences and Biotechnology, Hohenheim University, Stuttgart, Germany
    • ,
  • R. Carle

      Affiliations

    • Institute of Food Sciences and Biotechnology, Hohenheim University, Stuttgart, Germany
    • ,
  • J. Reichling

      Affiliations

    • Department of Biology, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany

References 

  1. Benencia F, Courrèges MC. Antiviral activity of sandalwood oil against herpes simplex viruses −1 and −2. Phytomedicine. 1999;6:119–123
  2. Bladt S, Wagner H. From the Zulu medicine to the European phytomedicine Umckaloabo®. Phytomedicine. 2007;14(S VI):2–4
  3. Brown DJ. Extract of Pelargonium sidoides: South African herbal remedy successfully treats acute bronchitis and tonsillopharyngitis. Herbal Gram. 2004;63:17–19
  4. Carson CF, Ashton L, Dry L, Smith DW, Riley TV. Melaleuca alternifolia (tea tree) oil gel (6%) for the treatment of recurrent herpes labialis. J. Antimicrob. Chemother. 2001;48:450–451
  5. Cassady KA, Whitley RJ. New therapeutic approaches to the alphaherpesvirus infections. J. Antimicrob. Chemother. 1997;39:119–128
  6. Conrad A, Hansmann C, Engels I, Daschner FD, Frank U. Extract of Pelargonium sidoides (EPs® 7630) improves phagocytosis, oxidative burst, and intracellular killing of human peripheral blood phagocytes in vitro. Phytomedicine. 2007;14(S VI):46–51
  7. Conrad A, Kolodziej H, Schulz. V. Pelargonium sidoides-Extrakt (EPs® 7630): Zulassung bestätigt Wirksamkeit und Verträglichkeit. Wien. Med. Wochenschr. 2007;157/13–14:331–336
  8. Christophers J, Clayton J, Craske J, Ward R, Collins P, Towbridge M, et al. Survey of resistance of herpes simplex virus to acyclovir in north-west England. Antimicrob. Agents Chemother. 1998;42:868–872
  9. De Clercq E. Antiviral drugs in current clinical use. J. Clin. Virol. 2004;30:115–133
  10. De Logu A, Loy G, Pellerano ML, Bonsignore L, Schivo ML. Inactivation of HSV-1 and HSV-2 and prevention of cell-to-cell virus spread by Santolina insularis essential oil. Antiviral Res. 2000;48:177–185
  11. Gödecke T, Kaloga M, Kolodziej H. A phenol glucoside, uncommon coumarins and flavonoids from Pelargonium sidoides DC. Ztschr. Naturforsch. 2005;60b:677–682
  12. Hutchings A. Zulu medicinal plants. Pietermaritzburg: Natal University Press; 1996;
  13. Kayser O, Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med. 1997;63:508–510
  14. Kayser O, Kolodziej H, Kiderlen AF. Immunomodulatory principles pf Pelargonium sidoides. Phytother. Res. 2001;15:122–126
  15. Koch C, Reichling J, Schneele J, Schnitzler P. Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine. 2008;15:71–78
  16. Kolodziej H. Traditionally used Pelargonium species: chemistry and biological activity of umckaloabo extracts and their constituents. Curr. Top. Phytochem. 2000;3:77–93
  17. Kolodziej H. Pelargonium reniforme and Pelargonium sidoides: their botany, chemistry and medicinal use. In:  Lis-Balchin M editors. Geranium and Pelargonium. London: Plenum Press; 2002;p. 262–290
  18. Kolodziej H, Kayser O. Pelargonium sidoides DC–Neueste Erkenntnisse zum Phyto-therapeutikum Umckaloabo. Z. Phytother. 1998;19:141–151
  19. Kolodziej H, Kiderlen A. In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs® 7630. Phytomedicine. 2007;14(S VI):18–26
  20. Kolodziej H, Kayser O, Radtke OA, Kiderlen AF, Koch E. Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine. 2003;10(Suppl. 4):18–24
  21. Latté KP, Kayser O, Tan N, Kaloga M, Kolodziej H. Unusual coumarin patterns of Pelargonium species forming the origin of the traditional herbal medicine umckaloabo. Z. Naturforsch. 2000;55c:528–533
  22. Matthys H, Eisebitt R, Seith B, Heger M. Efficacy and safety of an extract of Pelargonium sidoides (EPs® 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled trial. Phytomedicine. 2003;10(Suppl. 4):7–17
  23. Matthys H, Kamin W, Funk P, Heger M. Pelargonium sidoides preparation (EPs® 7630) in the treatment of acute bronchitis in adults and children. Phytomedicine. 2007;14(S VI):69–73
  24. Neugebauer P, Mickenhagen A, Siefer O, Walger M. Approach to pharmacological effects on ciliary beat frequency in cell cultures—exemplary measurements under pelargonium sidoides extract (EPs® 7630). Phytomedicine. 2005;12:47–52
  25. Nöldner M, Schötz K. Inhibition of lipopolysaccharide induced sickness behaviour by a dry extract from the roots of Pelargonium sidoides (EPs® 7630) in mice. Phytomedicine. 2007;14(S VI):27–31
  26. Nolkemper S, Reichling J, Stintzing FC, Carle R, Schnitzler P. Antiviral effect of aqueous extracts from species of the Lamiaceae family against herpes simplex virus type 1 and type 2 in vitro. Planta Med. 2006;72:1378–1384
  27. Reichling J. Plant–microbe interaction and secondary metabolites with antiviral, antibacterial and antifungal properties. In:  Wink M editors. Functions of Plant Secondary Metabolites and their Exploitation in Biotechnology. Annual Plant Review. vol. 3:Sheffield: Sheffield Acad. Press; 1999;p. 187–273
  28. Reichling J. Australian and New Zealand tea tree oil as the source of noval antiinfective agents. In:  Wildi E,  Wink M editor. Trends in Medicinal Plant Research. Dossenheim: Romneya-Verlag; 2001;p. 69–80
  29. Reichling J, Koch C, Stahl-Biskup E, Sojka C, Schnitzler P. Virucidal activity of a ß-triketone rich essential oil of Leptospermum scoparium (manuka oil) against HSV-1 and HSV-2 in cell culture. Planta Med. 2005;71:1123–1127
  30. Schnitzler P, Schön K, Reichling J. Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture. Pharmazie. 2001;56:343–347
  31. Schnitzler P, Koch C, Reichling J. Susceptibility of drug-resistant clinical HSV-1 strains to essential oils of ginger, thyme, hyssop and sandalwood. Antimicrob. Agents Chemother. 2007;51:1859–1862
  32. Schötz K, Nöldner M. Mass spectroscopic characterisation of oligomeric proanthocyanidins derived from an extract of Pelargonium sidoides roots (EPs® 7630) and pharmacological screening in CNS models. Phytomedicine. 2007;14(S VI):32–39
  33. Schuhmacher A, Reichling J, Schnitzler P. Virucidal effect of peppermint oil on the enveloped viruses herpes simplex virus type 1 and type 2 in vitro. Phytomedicine. 2003;10:504–510
  34. Sivropoulou A, Nikolaou C, Papanikolaou E, Kokkini S, Lanaras T, Arsenakis M. Antimicrobial, cytotoxic, and antiviral activities of Salvia fructicosa essential oil. J. Agric. Food Chem. 1997;45:3197–3201
  35. Sucato G, Wald A, Wakabayashi E, Vieira J, Corey L. Evidence of latency and reactivation of both herpes simplex virus (HSV)-1 and HSV-2 in the genital region. J. Infect. Dis. 1998;177:1069–1072
  36. Wittschier N, Faller G, Hensel A. An extract of Pelargonium sidoides (EPs® 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach. Phytomedicine. 2007;14(S VI):285–288

PII: S0944-7113(08)00117-7

doi: 10.1016/j.phymed.2008.06.009

Phytomedicine
Volume 15, Issue 12 , Pages 1108-1116 , December 2008

Article Tools

* Image Usage & Resolution