Phytomedicine
Volume 16, Issue 2 , Pages 215-221, March 2009

Chinese medicinal formula Guan-Xin-Er-Hao protects the heart against oxidative stress induced by acute ischemic myocardial injury in rats

  • F. Qin

      Affiliations

    • Laboratory of Ethnopharmacology and Institute of Integrated Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, PR China
    • ,
  • Y.-X. Liu

      Affiliations

    • Department of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China
    • ,
  • H.-W. Zhao

      Affiliations

    • Department of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China
    • ,
  • X. Huang

      Affiliations

    • Laboratory of Ethnopharmacology and Institute of Integrated Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, PR China
    • Corresponding Author InformationCorresponding author. Tel.: +867314327222; fax: +867314328386.
    • ,
  • P. Ren

      Affiliations

    • Laboratory of Ethnopharmacology and Institute of Integrated Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, PR China
    • ,
  • Z.-Y. Zhu

      Affiliations

    • Department of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China

Abstract 

Guan-Xin-Er-Hao (GXEH) is a Chinese medicine formula for treating ischemic heart diseases (IHD) and has a favorable effect. Our aim was to examine whether or not acute oral GXEH could protect the heart against myocardial infarction and apoptosis in acute myocardial ischemic rats. If so, we would explain the antioxidative mechanism involved. The left anterior descending coronary artery was occluded to induce myocardial ischemia in hearts of Sprague-Dawley rats. At the end of the 3h ischemic period (or 24h for infarct size), we measured the myocardial infarct size, myocardial apoptosis and the activities of antioxidative enzymes. GXEH reduced infarct size, myocardial apoptosis and the serum level of malondialdehyde (MDA), increased the activities of total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and GSH-peroxidase (GPX) activities and the serum level of glutathione (GSH). GXEH exerts significant cardioprotective effects against acute ischemic myocardial injury in rats, likely through its antioxidation and antilipid peroxidative properties, and thus may be used as a promising agent for both prophylaxis and treatment of IHD.

Keywords: Chinese medicine formula, Guan-Xin-Er-Hao, Salvia miltiorrhiza, Ligusticum chuanxiong, Paeonia lactiflora, Carthamus tinctorius, Dalbergia odorifera, Ischemic heart disease, Oxidative stress

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0944-7113(08)00161-X

doi:10.1016/j.phymed.2008.08.005

Phytomedicine
Volume 16, Issue 2 , Pages 215-221, March 2009

Article Tools

* Image Usage & Resolution