Phytomedicine
Volume 15, Issue 12 , Pages 1117-1124 , December 2008

Effects of extracts and neferine from the embryo of Nelumbo nucifera seeds on the central nervous system

  • Yumi Sugimoto

      Affiliations

    • Laboratory of Pharmacology, Department of Clinical Pharmacy, Yokohama College of Pharmacy, Matano-cho, Totsuka-ku, Yokohama 245-0066, Japan
    • Corresponding Author InformationCorresponding author. Tel.:+81458591300; fax:+81458591301.
    • ,
  • Sachiko Furutani

      Affiliations

    • Department of Pharmacology, Kobe Pharmaceutical University, Motoyamakita-machi, Higashianda-ku, Kobe 658-8558, Japan
    • ,
  • Atsuko Itoh

      Affiliations

    • Department of Organic Chemistry, Kobe Pharmaceutical University, Motoyamakita-machi, Higashianda-ku, Kobe 658-8558, Japan
    • ,
  • Takao Tanahashi

      Affiliations

    • Department of Organic Chemistry, Kobe Pharmaceutical University, Motoyamakita-machi, Higashianda-ku, Kobe 658-8558, Japan
    • ,
  • Hiroshi Nakajima

      Affiliations

    • Osaka City University, Research Center for Industry Innovation, Sugimoto, Sumiyoshi-ku, 558-8585 Osaka, Japan
    • ,
  • Hideo Oshiro

      Affiliations

    • Shanghai University of Traditional Chinese Medicine, Japan 1-7-20, Nishitenma Kita-ku, Osaka, Japan
    • ,
  • Shujian Sun

      Affiliations

    • Shanghai University of Traditional Chinese Medicine, Japan 1-7-20, Nishitenma Kita-ku, Osaka, Japan
    • ,
  • Jun Yamada

      Affiliations

    • Laboratory of Pharmacology, Department of Clinical Pharmacy, Yokohama College of Pharmacy, Matano-cho, Totsuka-ku, Yokohama 245-0066, Japan

References 

  1. Bernauer K. Pronuciferin, ein Benzylisochinolin-alkaloid mit para-Cyclohexadienon-Gruppierung. Helv. Chim. Acta. 1963;46:1783–1785
  2. In: Chiang Su New Medical College  editors. Zhong-yao-dai-ci-dian (Dictionary of Chinese Crude Drugs). Shanghai: Shanghai Scientific Technologic Publisher; 1978;p. 1806
  3. Furukawa H. On the alkaloids of Nelumbo nucifera Gaertn. IX. Alkaloids of loti embryo. (2). Structure of neferine, a new biscoclaurine alkaloid. Yakugaku Zasshi. 1965;85:335–338
  4. Furukawa H. Studies on the alkaloids of Nelumbo nucifera Gaertn. NMR spectra of liensinine type alkaloids. Yakugaku Zasshi. 1966;86:883–886
  5. Krane BR, Shamma M. The isoquinokine alkaloids. J. Nat. Prod. 1982;45:377–383
  6. Lister RG. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology. 1987;93:180–185
  7. Nishibe S, Tsukamoto H, Kinoshita H, Kitagawa S, Sakushima A. Alkaloids from embryo of the seed of Nelumbo nucifera. J. Nat. Prod. 1986;49:47–548
  8. Pan P-C, Chou Y-L, Sun T-T, Kao Y-S. Studies on the alkaloids of embryo loti, Nelumbo nucifera Gaertn. II. Structure of liensinine. Sci. Sin. 1962;11:321–336
  9. Pellow S, Chopin P, File SE, Briley M. Validation of open:closed arm entries in an elevated plus maze as a measure of anxiety in the rat. J. Neurosci. Methods. 1985;14:149–167
  10. Tomota M, Furukawa H, Yang T-H, Lin T-J. On the alkaloids of Nelumbo nucifera Gaertn. VIII. Studies on the alkaloids of loti embryo. (1) Structure of isoliensinine, a new biscoclaurine type alkaloid. Chem. Pharm. Bull. 1965;13:39–43
  11. Xiao J-H, Zhang J-H, Chen H-L, Feng X-L. Inhibitory effects of isoliensinine on bleomycin-induced pulmonary fibrosis in mice. Planta Med. 2005;71:225–230

PII: S0944-7113(08)00169-4

doi: 10.1016/j.phymed.2008.09.005

Phytomedicine
Volume 15, Issue 12 , Pages 1117-1124 , December 2008

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