Phytomedicine
Volume 16, Issue 1 , Pages 56-64 , January 2009

A pharmaceutical preparation of Salvia miltiorrhiza protects cardiac myocytes from tumor necrosis factor-induced apoptosis and reduces angiotensin II-stimulated collagen synthesis in fibroblasts

  • Shanhong Ling

      Affiliations

    • Department of Medicine, Monash University Central and Eastern Clinical School, Alfred Hospital, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61399030615; fax: +61399030018.
    • ,
  • Ruizhi Luo

      Affiliations

    • Institute of Research and Development (R&D), Tasly Pharmaceutical Co., LTD, Tianjin 300402, China
    • ,
  • Aozhi Dai

      Affiliations

    • Department of Medicine, Monash University Central and Eastern Clinical School, Alfred Hospital, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
    • ,
  • Zhixin Guo

      Affiliations

    • Institute of Research and Development (R&D), Tasly Pharmaceutical Co., LTD, Tianjin 300402, China
    • ,
  • Ruoling Guo

      Affiliations

    • Institute of Research and Development (R&D), Tasly Pharmaceutical Co., LTD, Tianjin 300402, China
    • ,
  • Paul A. Komesaroff

      Affiliations

    • Department of Medicine, Monash University Central and Eastern Clinical School, Alfred Hospital, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia

References 

  1. Balakumar P, Singh M. Anti-tumour necrosis factor-α therapy in heart failure: future directions. Basic Clin. Pharmacol. Toxicol. 2006;99:391–397
  2. Chen YH, Lin SJ, Ku HH, Shiao MS, Lin FY, Chen JW, et al. Salvianolic acid B attenuates VCAM-1 and ICAM-1 expression in TNF-alpha-treated human aortic endothelial cells. J. Cell Biochem. 2001;82:512–521
  3. De Smet PA. Herbal remedies. N. Engl. J. Med. 2002;347:2046–2056
  4. Ding M, Yuan YJ. Study on the mechanisms of an extract of Salvia miltiorrhiza on the regulation of permeability of endothelial cells exposed to tumour necrosis factor-alpha. J. Pharm. Pharmacol. 2007;59:1027–1033
  5. Ding M, Zhao GR, Yuan TJ, Guo ZX. Aqueous extract of Salvia miltiorrhiza regulates adhesion molecule expression of TNF-α-induced endothelial cells by blocking activation of nuclear factor κB. J. Cardiovasc. Pharmacol. 2005;45:516–524
  6. Fu J, Huang H, Liu J, Pi R, Chen J, Liu P. Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. Eur. J. Pharmacol. 2007;568:213–221
  7. Ji ZN, Liu GQ. Inhibition of serum deprivation-induced PC12 cell apoptosis by tanshinone IIA. Acta Pharmacol. Sin. 2001;22:459–462
  8. Li M, Zhao C, Wong RN, Goto S, Wang Z, Liao F. Inhibition of shear-induced platelet aggregation in rat by tetramethylpyrazine and salvianolic acid B. Clin. Hemorheol. Microcirc. 2004;31:97–103
  9. Lin R, Wang WR, Liu JT, Yang GD, Han CJ. Protective effects of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism. J. Ethnopharmacol. 2006;108:217–222
  10. Ling S, Dai A, Guo ZX, Komesaroff PA. Effects of a Chinese herb preparation on vascular cells in culture: mechanisms of cardiovascular protection. Clin. Exp. Pharma. Physiol. 2005;32:571–578
  11. Ling S, Nheu L, Dai A, Guo ZX, Komesaroff PA. Effects of four medicinal herbs on human vascular endothelial cells in culture. Int. J. Cardiol. 2007;8:(online publication)
  12. Ling S, Dai A, Guo ZX, Komesaroff PA. A preparation of herbal medicine Salvia miltiorrhiza reduces expression of intracellular adhesion molecule-1 and development of atherosclerosis in ApoE-deficient mice. J. Cardiovasc. Pharmacol. 2008;51:38–44
  13. Mani K. Programmed cell death in cardiac myocytes: strategies to maximize post-ischemic salvage. Heart Fail Rev. 2008;13:193–209
  14. Niu XL, Ichimori K, Yang X, Hirota Y, Hoshiai K, Li M, et al. Tanshinone IIA inhibits low density lipoprotein oxidation in vitro. Free Radical Res. 2000;33:305–312
  15. Ren DC, Du GH, Zhang JT. Inhibitory effect of the water-soluble extract of Salvia miltiorrhiza on neutrophil–endothelial adhesion. Jpn. J. Pharmacol. 2002;90:276–280
  16. Samuel CS, Unemori EN, Mookerjee I, Bathgate RAD, Layfield SL, Mak J, et al. Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo. Endocrinology. 2004;145:4125–4133
  17. Tang MK, Ren DC, Zhang JT, Du GH. Effect of salvianolic acids from Radix Salviae miltiorrhizae on regional cerebral blood flow and platelet aggregation in rats. Phytomedicine. 2002;9:405–409
  18. van Empel VP, Bertrand AT, Hofstra L, Crijns HJ, Doevendans PA, De Windt LJ. Myocyte apoptosis in heart failure. Cardiovasc. Res. 2005;67:21–29
  19. Xu M, Wang YP, Luo WB, Xuan LJ. Salvionolate inhibits proliferation and endothelin release in cultures rat mesangial cells. Acta Pharmacol. Sin. 2001;22:629–633
  20. Zhou GY, Zhao BL, Hou JW, Ma GE, Xin WJ. Protective effects of sodium tanshinone IIA sulphonate against adriamycin-induced lipid peroxidation in mice hearts in vivo and in vitro. Pharmacol. Res. 1999;40:487–491
  21. Zhou Z, Liu Y, Miao AD, Wang SQ. Protocatechuic aldehyde suppresses TNF-alpha-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells. Eur. J. Pharmacol. 2005;513:1–8

PII: S0944-7113(08)00172-4

doi: 10.1016/j.phymed.2008.09.008

Phytomedicine
Volume 16, Issue 1 , Pages 56-64 , January 2009

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