Phytomedicine
Volume 16, Issue 2 , Pages 227-232 , March 2009

Antinociceptive activity of swertiamarin isolated from Enicostemma axillare

  • V. Jaishree

      Affiliations

    • Department of Pharmaceutical Chemistry, J.S.S. College of Pharmacy, Ootacamund – 643 001, Tamil Nadu, India
  • ,
  • S. Badami

      Affiliations

    • Department of Pharmaceutical Chemistry, J.S.S. College of Pharmacy, Ootacamund – 643 001, Tamil Nadu, India
    • Corresponding Author InformationCorresponding author at: Sree Siddaganga College of Pharmacy, B.H. Road, Tumkur-572102, India. Tel.: +918162273331; fax: +918162252792.
  • ,
  • M. Rupesh Kumar

      Affiliations

    • Bharati College of Pharmacy, K.M. Doddi, Mandya, Karnataka, India
  • ,
  • T. Tamizhmani

      Affiliations

    • Bharati College of Pharmacy, K.M. Doddi, Mandya, Karnataka, India

References 

  1. Ahmadiani A, Fereidoni M, Semnanian S, Kamalinejad M, Sureni S. Antinociceptive and anti-inflammatory effects of Sambucus ebulus rhizome extract in rats. J. Ethnopharmacol. 1998;61:229–235
  2. Ahsana D, Shaheen F, Sabira N, Talat R, Sadia Z, Muhammad A, et al. Analgesic and antioxidant activity of mangiferin and its derivatives: the structure activity relationship. Biol. Pharm. Bull. 2005;28:596–600
  3. Almeida RN, Hiruma CA, Barbosa Filho JM. Analgesic effect of rotundifolone in rodents. Fitoterapia. 1996;67:334–338
  4. Amaral JF, Silva MIG, Neto MRA, Neto PFT, Moura BA, et al. Antinociceptive effect of the monoterpene R-(_)-limonene in mice. Biol. Phar. Bull. 2007;30:1217–1220
  5. Anonymous . Quality Control Methods for Medicinal Plant Materials. WHO; 1998;
  6. Bas E, Recio MC, Abdallah M, Manez S, Giner RM, Nicolas MC, et al. Inhibition of the pro-inflammatory mediators production and anti-inflammatory effect of the iridoid Scrovalentinoside. J. Ethnopharmacol. 2007;110:419–427
  7. Berkenkopf JW, Weichmann BM. Production of prostacyclin in mice following intraperitoneal injection of acetic acid, phenyl benzoquinone and zymosan, its role in the writhing response. Prostag. Leukotr. Ess. 1988;36:693–709
  8. Bruneton J. Pharmacognosy, Phytochemistry and Medicinal Plants. Hampshire: Intercept Ltd.; 1995;pp. 475–485
  9. Chakraborty A, Devi RKB, Rita S, Sharatchandra K, Singh TI. Preliminary studies on anti-inflammatory and analgesic activity of Spilanthes acmella in experimental animal models. Indian J. Pharmacol. 2004;36:148–150
  10. Dinda B, Debnath S, Harigaya Y. Naturally occurring secoiridoids and bioactivity of naturally occurring iridoids and secoiridoids. A review, Part 2. Chem. Pharm. Bull. 2007;55:689–728
  11. Dykstra LA, Woods JH. A tail withdrawal procedure for assessing analgesic activity in Rhesus monkeys. J. Pharmacol. Meth. 1986;15:263–269
  12. Ghisalberti EL. Biological and pharmacological activity of naturally occurring iridoids and secoiridoids. Phytomedicine. 1998;5:147–163
  13. Goncalves JCR, Oliveira FDS, Benedito RB, Sousa DPD, Almeida RND, et al. Antinociceptive activity of (_)-carvone: evidence of association with decreased peripheral nerve excitability. Biol. Pharm. Bull. 2008;31:1017–1020
  14. Jaishree, V., Badami, S., Suresh, B., 2008. In vitro antioxidant activity of Enicostemma axillare, J. Health Sci., in press.
  15. Janssen P, Neimemegeers CJE, Dony JGH. The inhibitory effects of fentanyl and other morphine like analgesics on the warm water induced tail withdrawal reflex in rats. Arzneimittel Forschung. 1963;13:502–507
  16. Kavimani S, Manisenthilkumar KT. Effect of methanolic extract of Enicostemma littorale on Dalton's ascitic lymphoma. J. Ethnopharmacol. 2000;71:349–352
  17. Kim MS, Cheong YP, So HS, Lee KM, Kime TY, et al. Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes. Biochem. Pharmacol. 2001;6:779–786
  18. Kou J, Ni Y, Li N, Wang J, Liu L, Jiang ZH. Analgesic and antiinflammatory activities of total extract and individual fractions of Chinese medicinal ants polyrhachis lamellidens. Biol. Pharm. Bull. 2005;28:176–180
  19. Kulkarni SK. Hand Book of Experimental Pharmacology. New Delhi, India: Vallabh Prakashan; 1999;p. 117
  20. Kumarsamy Y, Nahar L, Cox PJ, Jaspars M, Sarker SD. Bioactivity of secoiridoid glycosides from Centaurium erythraea. Phytomedicine. 2003;10:344–347
  21. Mandal S, Jain R, Mukhopadhyay S. Naturally occurring iridoids with pharmacological activity. Indian J. Pharm. Sci. 1998;60:123–127
  22. Maroo J, Vasu VT, Gupta S. Dose dependent hypoglycemic effect of aqueous extract of Enicostemma littorale Blume in alloxan induced diabetic rats. Phytomedicine. 2003;10:196–199
  23. Masafumi K, Masao K. Studies on the constituents of Swertia japonica Makino I on the structures of new secoiridoid diglycosides. Chem. Pharm. Bull. 2004;52:1210–1214
  24. Murali B, Upadhyaya UM, Goyal RK. Effect of chronic treatment with Enicostemma littorale in non-insulin-dependent diabetic (NIDDM) rats. J. Ethnopharmacol. 2002;81:199–204
  25. Parimala Devi B, Boominathan R, Subhash CM. Anti-inflammatory, analgesic and antipyretic properties of Clitoria ternetea root. Fitoterapia. 2003;74:345–349
  26. Rokyta R, Holecek V, Pekarkova I, Krejcova J, Racek J, et al. Free radicals after painful stimulation are influenced by antioxidants and analgesics. Neuroendocrinol. Lett. 2003;24:304–309
  27. Sadique J, Chandra T, Thenmozhi V, Elango V. The anti-inflammatory activity of Enicostemma littorale and Mullogo cervina. Biochem. Med. Metab. Biol. 1987;37:167–176
  28. Takayama H. Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyma speciosa. Chem. Pharm. Bull. 2004;52:916–928
  29. Takei H, Nakauchi K, Yoshizaki F. Analysis of swertiamarin in Swertia herb and preparations containing this crude drug by capillary electrophoresis. Anal. Sci. 2001;17:885–888
  30. Varier PS. Indian Medicinal Plants. vol. 2. Chennai, India: Orient Longman (Pvt) Ltd.; 1994;pp. 374–376
  31. Vasu VT, Modi H, Thaikoottathil JV, Gupta S. Hypolipidaemic and antioxidant effect of Enicostemma littorale Blume aqueous extract in cholesterol fed rats. J. Ethnopharmacol. 2005;101:277–282
  32. Vasudevan M, Gunnam KK, Parle M. Antinociceptive and anti-inflammatory properties of Daucus carota seeds extract. J. Health Sci. 2006;52:598–606
  33. Vijayvargia R, Kumar M, Gupta S. Hypoglycemic effect of aqueous extract of Enicostemma littorale Blume (chhota chirayata) on alloxan induced diabetes mellitus in rats. Indian J. Exp. Biol. 2000;38:781–784
  34. Vishwakarma SL, Rajani M, Bagul MS, Goyal RK. A rapid method for the isolation of swertiamarin from Enicostemma littorale. Pharm. Biol. 2004;42:400–403

PII: S0944-7113(08)00174-8

doi: 10.1016/j.phymed.2008.09.010

Phytomedicine
Volume 16, Issue 2 , Pages 227-232 , March 2009