Phytomedicine
Volume 16, Issue 2 , Pages 244-251 , March 2009

Determination and pharmacokinetic study of taxifolin in rabbit plasma by high-performance liquid chromatography

  • Olga N. Pozharitskaya

      Affiliations

    • Interregional Center “Adaptogen”, 47/5, Piskarevsky pr., 195067 St.-Petersburg, Russia
    • Saint-Petersburg Institute of Pharmacy, 47/33, Piskarevsky pr., 195067 St.-Petersburg, Russia
  • ,
  • Marina V. Karlina

      Affiliations

    • Saint-Petersburg Institute of Pharmacy, 47/33, Piskarevsky pr., 195067 St.-Petersburg, Russia
  • ,
  • Alexander N. Shikov

      Affiliations

    • Interregional Center “Adaptogen”, 47/5, Piskarevsky pr., 195067 St.-Petersburg, Russia
    • Saint-Petersburg Institute of Pharmacy, 47/33, Piskarevsky pr., 195067 St.-Petersburg, Russia
    • Corresponding Author InformationCorresponding author at: Interregional Center “Adaptogen”, 47/5, Piskarevsky pr., 195067 St.-Petersburg, Russia. Tel.: +78125452230; fax: +78123225605.
  • ,
  • Vera M. Kosman

      Affiliations

    • Interregional Center “Adaptogen”, 47/5, Piskarevsky pr., 195067 St.-Petersburg, Russia
  • ,
  • Marina N. Makarova

      Affiliations

    • Saint-Petersburg Institute of Pharmacy, 47/33, Piskarevsky pr., 195067 St.-Petersburg, Russia
  • ,
  • Valery G. Makarov

      Affiliations

    • Interregional Center “Adaptogen”, 47/5, Piskarevsky pr., 195067 St.-Petersburg, Russia
    • Saint-Petersburg Institute of Pharmacy, 47/33, Piskarevsky pr., 195067 St.-Petersburg, Russia

References 

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  5. Geodakyan SV, Voskoboinikova IV, Kolesnik JA, Tjukavkina NA, Litvinenko VI, Glyzin VI. High-performance liquid chromatographic method for the determination of mangiferin, likviritin and dihydroquercetin in rat plasma and urine. J. Chromatogr. 1992;577:371–375
  6. Grimm T, Skrabala R, Chovanova Z, Muchova J, Sumegova K, Liptakova A, et al. Single and multiple dose pharmacokinetics of maritime pine bark extract (pycnogenol) after oral administration to healthy volunteers. BMC Clin. Pharmacol. 2006;6:4
  7. ICH, Q2A, 1994. Harmonised tripartite guideline, text on validation of analytical procedures, IFPMA. In: Proceedings of the International Conference on Harmonization, Geneva, March 1994; 1.
  8. ICH, Q2B, 1996. Harmonised tripartite guideline, validation of analytical procedure: methodology, IFPMA. In: Proceedings of the International Conference on Harmonization, Geneva, March 1996; 1.
  9. Karlina M, Pozharitskaya O, Shikov A. Self-microemulsifying drug delivery systems as nanosystems for bioavailability enhancement of taxifolin in vitro. Planta Med. 2007;73:905–906
  10. Manach C, Williamson G, Morand C, Scalbert A, Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 2005;81:230S–242S
  11. Piskula MK. Factors affecting flavonoids absorption. BioFactors. 2000;12:175–180
  12. Plotnikov MB, Aliev OI, Maslov MJ, Vasiliev AS, Tjukavkina NA. Correction of the high blood viscosity syndrome by a mixture of diquertin and ascorbic acid in vitro and in vivo. Phytother. Res. 2003;17:276–278
  13. Plotnikov MB, Plotnikov DM, Aliev OI, Maslov MJ, Vasiliev AS, Alifirova VM, et al. Hemorheological and antioxidant effects of ascovertin in patients with sclerosis of cerebral arteries. Clin. Hemorheol. Microcirc. 2004;30:449–452
  14. Plotnikov MB, Tjukavkina NA, Plotnikova TM. Medicinal Preparations on the Base of Dihydroquerzetine. Tomsk: Publishing House of Tomsk University; 2005;
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  16. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J. Nutr. 2000;130:2073S–2085S
  17. Shikov A, Pozharitskaya O, Karlina M, Makarov V. Self-microemulsifying drug delivery system as nanosystems for bioavailability enhancement of flavonoids in vitro. Eur. J. Pharm. Sci. 2008;34(Suppl. 1):S29
  18. Shikov AN, Pozharitskaya ON, Miroshnik I, Mirza S, Karlina MV, Hirsjärvi S, et al. Nanosystems as a way of improving the bioavailability of natural compounds. Farmatsiia-Moskva. 2008;7:53–57
  19. Urakova I, Pozharitskaya O, Shikov A, Makarov V, Tikhonov V. Nanosystems with taxifolin for solid dosage form and its bioavailability in vitro. Planta Med. 2007;73:905
  20. Voskoboinikova IV, Tjukavkina NA, Geodakyan SV, Kolesnik YA, Kolhir VK, Zjuzin VA, et al. Experimental pharmacokinetics of biologically active plant phenolic compounds III. Pharmacokinetics of dihydroquercetin. Phytother. Res. 1993;7:208–210
  21. Walle T. Absorption and metabolism of flavonoids. Free Radical Biol. Med. 2004;36:829–837
  22. Zenkevich IG, Eschenko AY, Makarova SV, Makarov VG. Unusual chemical transformations of natural flavonoids. Planta Med. 2006;72:1070
  23. Zherdev, V., Kolyvanov, G., Litvin, A., Sariev, A., Kolesnik, Yu., Titova, E., Tikhonov, V., Shmatkov, D., 2007. Pre-clinical pharmacokinetics of dihydroquercetin. In: Apers, S., Budantsev, A., Carrier, J., Choi, Y., Dadali, V., Hankemeier, T., van der Heijden, R., Hiltunen, R., Makarov, V., Makarova, M., Pozharitskaya, O., Samylina, I., Shikov, A., Shikh, E., Sukhanov, B., Sychev, D., Tutelyan, V., Verpoorte, R., Vladimirov, Yu., Witkamp, R., Yakovlev, G., Zenkevich, I., (Eds.), Abstracts Book of Phytopharm 2007. p. 76.

PII: S0944-7113(08)00188-8

doi: 10.1016/j.phymed.2008.10.002

Phytomedicine
Volume 16, Issue 2 , Pages 244-251 , March 2009