Phytomedicine
Volume 16, Issue 5 , Pages 451-455 , May 2009

Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro

  • Xiao-Ping Liu

      Affiliations

    • Department of Pharmacology, Wannan Medical College, Wuhu, Anhui, PR China
    • Corresponding Author InformationCorresponding author. Tel./fax: +865533932619.
    • ,
  • Christopher E.P. Goldring

      Affiliations

    • Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, Merseyside, UK
    • ,
  • Hai-Yi Wang

      Affiliations

    • Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, Merseyside, UK
    • ,
  • Ian M. Copple

      Affiliations

    • Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, Merseyside, UK
    • ,
  • Neil R. Kitteringham

      Affiliations

    • Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, Merseyside, UK
    • ,
  • B. Kevin Park

      Affiliations

    • Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, Merseyside, UK

References 

  1. Ahmad M, Saleem S, Ahmad AS, Yousuf S, Ansari MA, Khan MB, et al. Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine-induced Parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences. J. Neurochem. 2005;93:94–104
  2. Ban N, Takahashi Y, Takayama T, Kura T, Katahira T, Sakamaki S, et al. Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide. Cancer Res. 1996;56:3577–3582
  3. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding. Anal. Biochem. 1976;72:248–254
  4. Bridi R, Crossetti FP, Steffen VM, Henriques AT. The antioxidant activity of standardized extract of Ginkgo biloba (EGb 761) in rats. Phytother. Res. 2001;15:449–451
  5. Chen JX, Zeng H, Chen X, Su CY, Lai CC. Induction of heme oxygenase-1 by Ginkgo biloba extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage. Pharmacol. Res. 2001;43:63–69
  6. Chen SH, Liang YC, Chao JC, Tsai LH, Chang CC, Wang CC, et al. Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats. World J. Gastroenterol. 2005;11:3746–3750
  7. Coles B, Ketterer B. The role of glutathione and glutathione transferases in chemical carcinogenesis. Crit. Rev. Biochem. Mol. Biol. 1990;25:47–70
  8. DeFeudis, F.V., 1998. Ginkgo biloba extract (EGb 761): from chemistry to the clinic. Ullstein-Medical, Wiesbaden.
  9. DeFeudis FV, Papadopoulos V, Drieu K. Ginkgo biloba extracts and cancer: a research area in its infancy. Fundam. Clin. Pharmacol. 2003;17:405–417
  10. Desmots F, Rissel M, Loyer P, Turlin B, Guillouzo A. Immunohistological analysis of glutathione transferase A4 distribution in several human tissues using a specific polyclonal antibody. J. Histochem. Cytochem. 2001;49:1573–1579
  11. Droy-Lefaix MT, Cluzel J, Menerath JM, Bonhomme B, Doly M. Antioxidant effect of a Ginkgo biloba extract (EGb 761) on the retina. Int. J. Tissue React. 1995;17:93–100
  12. Gohil K, Moy RK, Farzin S, Maguire JJ, Packer L. mRNA expression profile of a human cancer cell line in response to Ginkgo biloba extract: induction of antioxidant response and the Golgi system. Free Radic. Res. 2000;33:831–849
  13. Grignon DJ, Abdel-Malak M, Mertens WC, Sakr WA, Shepherd RR. Glutathione S-transferase expression in renal cell carcinoma: a new marker of differentiation. Mod. Pathol. 1994;7:186–189
  14. Griffiths K, Morton MS, Denis I. Certain aspects of molecular endocrinology that relate to the influence of dietary factors on the pathogenesis of prostate cancer. Eur. Urol. 1999;35:443–455
  15. Habig WH, Jakoby WB. Assays for differentiation of glutathione S-transferases. Methods Enzymol. 1981;77:398–405
  16. Hamada S, Kamada M, Furumoto H, Hirao T, Aono T. Expression of glutathione S-transferase-pi in human ovarian cancer as an indicator of resistance to chemotherapy. Gynecol. Oncol. 1994;52:313–319
  17. Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol. 1995;30:445–600
  18. Henderson CJ, Smith AG, Ure J, Brown K, Bacon EJ, Wolf CR. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc. Natl. Acad. Sci. USA. 1998;95:5275–5280
  19. Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 1997;236:313–322
  20. Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999;13:76–86
  21. Ketterer B. A bird's eye view of the glutathione transferase field. Chem.–Biol. Interact. 2001;138:27–42
  22. Kleijnen J, Knipschild P. Ginkgo biloba. Lancet. 1992;340:1136–1139
  23. Liu XP, Goldring CE, Copple IM, Wang HY, Wei W, Kitteringham NR, et al. Extract of Ginkgo biloba induces the phase 2 genes through Keap1–Nrf2–ARE signaling pathway. Life Sci. 2007;80:1586–1591
  24. Long DJ, Waikel RL, Wang XJ, Perlaky L, Roop DR, Jaiswal AK. NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis. Cancer Res. 2000;60:5913–5915
  25. McMahon M, Itoh K, Yamamoto M, Hayes JD. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J. Biol. Chem. 2003;278:21592–21600
  26. Mohammadzadeh GS, Nasseri Moghadam S, Rasaee MJ, Zaree AB, Mahmoodzadeh H, Allameh A. Measurement of glutathione S-transferase and its class-pi in plasma and tissue biopsies obtained after laparoscopy and endoscopy from subjects with esophagus and gastric cancer. Clin. Biochem. 2003;36:283–288
  27. Mutoh M, Takahashi M, Fukuda K, Matsushima-Hibiya Y, Mutoh H, Sugimura T, et al. Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. Carcinogenesis. 2000;21:959–963
  28. Nelson CP, Kidd LC, Sauvageot J, Isaacs WB, DeMarzo AM, Groopman JD, et al. Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1. Cancer Res. 2001;61:103–109
  29. O’Brien M, Kruh GD, Tew KD. The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance. J. Pharmacol. Exp. Ther. 2000;294:480–487
  30. Papadopoulos V, Kapsis A, Li H, Amri H, Hardwick M, Culty M, et al. Drug-induced inhibition of the peripheral-type benzodiazepine receptor expression and cell proliferation in human breast cancer cells. Anticancer Res. 2000;20:2835–2847
  31. Prestera T, Holtzclaw WD, Zhang Y, Talalay P. Chemical and molecular regulation of enzymes that detoxify carcinogens. Proc. Natl. Acad. Sci. USA. 1993;90:2965–2969
  32. Raza H, Awasthi YC, Zaim MT, Eckert RL, Mukhtar H. Glutathione S-transferases in human and rodent skin: multiple forms and species-specific expression. J. Invest. Dermatol. 1991;96:463–467
  33. Rong Y, Geng Z, Lau BH. Ginkgo biloba attenuates oxidative stress in macrophages and endothelial cells. Free Radic. Biol. Med. 1996;20:121–127
  34. Tidefelt U, Elmhorn-Rosenborg A, Paul C, Hao XY, Mannervik B, Eriksson LC. Expression of glutathione transferase pi as a predictor for treatment results at different stages of acute nonlymphoblastic leukemia. Cancer Res. 1992;52:3281–3285
  35. Townsend DM, Tew KD. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene. 2003;22:7369–7375
  36. Tsuchida S, Sato K. Glutathione transferases and cancer. Crit. Rev. Biochem. Mol. Biol. 1992;27:337–384
  37. Zhou Z, Zheng S. The missing link in Ginkgo evolution. Nature. 2003;423:821–822

PII: S0944-7113(08)00212-2

doi: 10.1016/j.phymed.2008.11.001

Phytomedicine
Volume 16, Issue 5 , Pages 451-455 , May 2009

Article Tools

* Image Usage & Resolution