Phytomedicine
Volume 17, Issue 5 , Pages 379-382, April 2010

Antiprotozoal activity of Betulinic acid derivatives

  • D.B. Domínguez-Carmona

      Affiliations

    • Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43, No. 130, Col. Chuburná, Mérida, Yucatán 97200, México
    • ,
  • F. Escalante-Erosa

      Affiliations

    • Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43, No. 130, Col. Chuburná, Mérida, Yucatán 97200, México
    • ,
  • K. García-Sosa

      Affiliations

    • Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43, No. 130, Col. Chuburná, Mérida, Yucatán 97200, México
    • ,
  • G. Ruiz-Pinell

      Affiliations

    • Instituto de Investigaciones Fármaco-Bioquímicas, Universidad Mayor de San Andrés (IIFB-UMSA), Miraflores, La Paz, Bolivia
    • ,
  • D. Gutierrez-Yapu

      Affiliations

    • Instituto de Investigaciones Fármaco-Bioquímicas, Universidad Mayor de San Andrés (IIFB-UMSA), Miraflores, La Paz, Bolivia
    • ,
  • M.J. Chan-Bacab

      Affiliations

    • Departamento de Microbiología Ambiental y Biotecnología, Universidad Autónoma de Campeche, Campeche, Campeche, México
    • ,
  • A. Giménez-Turba

      Affiliations

    • Instituto de Investigaciones Fármaco-Bioquímicas, Universidad Mayor de San Andrés (IIFB-UMSA), Miraflores, La Paz, Bolivia
    • ,
  • L.M. Peña-Rodríguez

      Affiliations

    • Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43, No. 130, Col. Chuburná, Mérida, Yucatán 97200, México
    • Corresponding Author InformationCorresponding author. Tel.: +529999428330x159; fax: +529999813900.

published online 14 September 2009.

Abstract 

Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity.

Keywords: Pentalinon andriexii, Betulinic acid, Leishmanicidal, Trypanocidal, Antiplasmodial

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PII: S0944-7113(09)00205-0

doi:10.1016/j.phymed.2009.08.002

Phytomedicine
Volume 17, Issue 5 , Pages 379-382, April 2010

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