ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz
Abstract
Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10
μM concentration.
Keywords: In vitro ACE inhibitory activity, Astilbin, Erythroxylum gonocladum
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PII: S0944-7113(09)00237-2
doi:10.1016/j.phymed.2009.09.008
© 2009 Elsevier GmbH. All rights reserved.
