Journal Home
Search for

Volume 17, Issue 5, Pages 383-387 (April 2010)


View previous. 16 of 16

ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz

M.D. Lucas-Filhoa, G.C. Silvab, S.F. Cortesb, T.R. Mares-Guiac, V. Perpétua Ferrazd, C.P. Serraa, F.C. BragaeCorresponding Author Informationemail addressemail address

published online 30 October 2009.

Abstract 

Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10μM concentration.

a School of Pharmacy, Universidade Federal de Ouro Preto, Ouro Preto, Brazil

b Departament of Pharmacology, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

c Department of Biochemistry and NUCEL – Cell and Molecular Therapy Center, IQ, Universidade de São Paulo, São Paulo, Brazil

d Department of Chemistry, ICEX, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

e Faculty of Pharmacy, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, campus Pampulha, Belo Horizonte, Brazil

Corresponding Author InformationCorresponding author. Tel.: +553134096951; fax: +553134096935.

PII: S0944-7113(09)00237-2

doi:10.1016/j.phymed.2009.09.008


View previous. 16 of 16