Phytomedicine
Volume 17, Issue 10 , Pages 789-793, August 2010

Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus

  • K.K. Bhutani

      Affiliations

    • Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Mohali-160062, Punjab, India
    • Corresponding Author InformationCorresponding author.
    • ,
  • A.T. Paul

      Affiliations

    • Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Mohali-160062, Punjab, India
    • ,
  • W. Fayad

      Affiliations

    • Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and Hospital, Stockholm, Sweden
    • ,
  • S. Linder

      Affiliations

    • Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and Hospital, Stockholm, Sweden

published online 22 February 2010.

Abstract 

A series of Sarsapogenin and Diosgenin derived steroidal constituents (1-12), isolated from Solanum xanthocarpum and Asparagus racemosus were screened for their ability to induce cell death and apoptosis of colon carcinoma cells. The carbohydrate moieties linked to the steroid backbones were found to strongly influence cytotoxic activity and cell death mode (apoptosis or necrosis). Compound 10, from A. racemosus was found to be a potent inducer of apoptosis.

Keywords: Anticancer activity, Apoptosis, Sarsapogenin and Diosgenin derived steroidal constituents, Glycoalkaloids, Solanum xanthocarpum, Asparagus racemosus

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0944-7113(10)00033-4

doi:10.1016/j.phymed.2010.01.017

Phytomedicine
Volume 17, Issue 10 , Pages 789-793, August 2010

Article Tools

* Image Usage & Resolution