Phytomedicine
Volume 18, Issue 5 , Pages 356-361, 15 March 2011

Lycopene and ellagic acid prevent testicular apoptosis induced by cisplatin

  • Gaffari Türk

      Affiliations

    • Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Fırat University, 23119 Elazığ, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 424 237 00 00/3892; fax: +90 424 238 81 73.
    • ,
  • Ali Osman Çeribaşı

      Affiliations

    • Department of Pathology, Faculty of Veterinary Medicine, Fırat University, 23119 Elazığ, Turkey
    • ,
  • Engin Şahna

      Affiliations

    • Department of Pharmacology, Faculty of Medicine, Fırat University, 23119 Elazığ, Turkey
    • ,
  • Ahmet Ateşşahin

      Affiliations

    • Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Fırat University, 23119 Elazığ, Turkey

published online 26 August 2010.

Abstract 

The aim of this study was to investigate the possible protective effects of lycopene (LC) and ellagic acid (EA) on cisplatin (CP)-induced testicular apoptosis in male rats. The control group was treated with placebo; LC, EA and CP groups were given alone LC, EA and CP, respectively; the CP+LC group was treated with a combination of CP and LC; and the CP+EA group was treated with a combination of CP and EA. Although CP significantly increased the number of Bax-positive (apoptotic) cells it had no effect on the number of Bcl-2-positive (antiapoptotic) cells compared with the control group. Administration of CP caused significant increase in lipid peroxidation and nonsignificant decrease in superoxide dismutase (SOD) activity along with some histopathological lesions in testicular tissue. However, combined treatments of LC or EA in addition to CP tended to prevent the CP-induced testicular apoptosis, histopathological lesions and lipid peroxidation.

Keywords: Cisplatin, Lycopene, Ellagic acid, Apoptosis, Lipid peroxidation, Testis

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PII: S0944-7113(10)00230-8

doi:10.1016/j.phymed.2010.07.008

Phytomedicine
Volume 18, Issue 5 , Pages 356-361, 15 March 2011

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