Soy isoflavones, diet and physical exercise modify serum cytokines in healthy obese postmenopausal women

Llaneza, Placido; González, Celestino; Fernandez-Iñarrea, José; Alonso, Ana; Diaz, Fernando; Arnott, Ignacio; Ferrer-Barriendos, Javier

doi:10.1016/j.phymed.2010.07.011

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Volume 18, Issue 4 , Pages 245-250, 15 February 2011

Soy isoflavones, diet and physical exercise modify serum cytokines in healthy obese postmenopausal women

Placido Llaneza
- Department of Obstetrics and Gynecology, Central University Hospital of Asturias, C/Celestino Villamil s/n, 33006 Oviedo, Asturias, Spain
- Corresponding author. Tel.: +34 98510800; fax: +34 985104198.
Celestino González
- Department of Functional Biology, Physiology Area, University of Oviedo, C/Julián Clavería s/n, 33006 Oviedo, Spain
José Fernandez-Iñarrea
- Department of Obstetrics and Gynecology, Cabueñes Hospital, Cabueñes s/n, 33203 Gijón, Spain
Ana Alonso
- Department of Functional Biology, Physiology Area, University of Oviedo, C/Julián Clavería s/n, 33006 Oviedo, Spain
Fernando Diaz
- Central University Hospital of Asturias, Department of Functional Biology, Physiology Area, University of Oviedo, C/Julián Clavería s/n, 33006 Oviedo, Spain
Ignacio Arnott
- Department of Obstetrics and Gynecology, Central University Hospital of Asturias, C/Celestino Villamil s/n, 33006 Oviedo, Asturias, Spain
Javier Ferrer-Barriendos
- Department of Obstetrics and Gynecology, Central University Hospital of Asturias, C/Celestino Villamil s/n, 33006 Oviedo, Asturias, Spain

published online 23 August 2010.

Abstract

Objectives

Evaluate the effect of diet, physical exercise, and a daily oral intake of a soy isoflavones extract (Fisiogen^®) contained 200mg of Glycine max, which corresponded to 80mg of isoflavone (60.8mg of genistein, 16mg of daidzein and 3.2mg of glicitein) on leptin and other adipokines plasma levels in healthy obese postmenopausal women.

Methods

A multicentric randomized longitudinal prospective cohort study was conducted in a sample of 87 healthy obese postmenopausal women. Patients were randomly assigned to a 1200kcal diet and exercise group (control group) or a group of 1200kcal diet, exercise, and daily oral intake of daily oral intake of a soy isoflavones extract (Fisiogen^®) contained 200mg of Glycine max, which corresponded to 80mg of isoflavone (60.8mg of genistein, 16mg of daidzein and 3.2mg of glicitein) (soy isoflavones group) along 6 months. Main outcome measures were: anthropometric measures, body composition, leptin, adiponectin, TNF-alpha, homocysteine, C-reactive protein, glucose, insulin, lipid profile and oestradiol serum levels, Kupperman index and Cervantes Scale.

Results

Mean serum leptin and TNF-alpha levels declined after 6 months in both groups of the study, but only women in the soy isoflavones group showed a significant increase of mean serum levels of adiponectin.

Conclusions

Diet, physical exercise and daily oral intake of a soy isoflavones extract (Fisiogen^®) contained 200mg of Glycine max, which corresponded to 80mg of isoflavone (60.8mg of genistein, 16mg of daidzein and 3.2mg of glicitein) have a beneficial effect on serum leptin, adiponectin and TNF-α in healthy obese postmenopausal women after 6 months of treatment.

Keywords: Obesity, Postmenopausal, Soy isoflavones, Diet, Physical exercise, Adipokines